4XAK

Crystal structure of potent neutralizing antibody m336 in complex with MERS Co-V RBD

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, B)	Spike glycoprotein	polymer	252	27625.0	2	UniProt (K9N5Q8) Pfam (PF09408)	Human coronavirus EMC (HCoV-EMC)	S glycoprotein,E2,Peplomer protein
2	B, E (H, D)	Heavy chain of neutralizing antibody m336	polymer	252	26525.6	2		Homo sapiens (human)
3	C, F (L, E)	Light chain of neutralizing antibody m336	polymer	214	23211.8	2		Homo sapiens (human)
4	G, H, K, L (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
5	I, J (L)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
6	M, N, O, P, Q... (A, H, L, B, D...)	water	water		18.0	236	Chemie (HOH)

Sequence modifications

A, B: 367 - 601 (UniProt: K9N5Q8)

PDB	External Database	Details
Gly 602	-	expression tag
Ser 603	-	expression tag
Leu 604	-	expression tag
Glu 605	-	expression tag
Val 606	-	expression tag
Leu 607	-	expression tag
Phe 608	-	expression tag
Gln 609	-	expression tag
Gly 610	-	expression tag
Pro 611	-	expression tag
Gly 612	-	expression tag
His 613	-	expression tag
His 614	-	expression tag
His 615	-	expression tag
His 616	-	expression tag
His 617	-	expression tag
His 618	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	154724.7
Non-Polymers*	Number of molecules	6
	Total formula weight	1069.0
All*	Total formula weight	155793.7

*Water molecules are not included.