4X0N

Porcine pancreatic alpha-amylase in complex with helianthamide, a novel proteinaceous inhibitor

Summary for 4X0N
DescriptorPancreatic alpha-amylase, Helianthamide, CHLORIDE ION, ... (6 entities in total)
Functional Keywordsamylase, inhibitor, diabetes, protein inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSus scrofa (Pig)
More
Total number of polymer chains2
Total formula weight60236.67
Authors
Williams, L.K.,Brayer, G.D. (deposition date: 2014-11-21, release date: 2015-11-25, Last modification date: 2020-01-08)
Primary citationAguda, A.,Andersen, R.J.,Brayer, G.D.,Keyzers, R.,Nguyen, N.T.,Tarling, C.A.,Tysoe, C.,Williams, L.K.,Withers, S.G.,Zhang, X.
Structural Templating and Guided Refolding of the Potent Naturally Occurring Peptide Helianthamide Within the Active Site of Amylase, a Diabetes and Obesity Therapeutic Target
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.6001 Å)
Structure validation
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PDB entries from 2021-06-16