4WZ6

Human CFTR aa389-678 (NBD1), deltaF508 with three solubilizing mutations, bound ATP

Summary for 4WZ6

Entry DOI	10.2210/pdb4wz6/pdb
Descriptor	Cystic fibrosis transmembrane conductance regulator, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	atpase, hydrolase, atp/adp binding, atp binding protein
Biological source	Homo sapiens (Human)
Cellular location	Apical cell membrane ; Multi-pass membrane protein {ECO:0000269\|Ref: P13569
Total number of polymer chains	1
Total formula weight	32915.24
Authors	Byrnes, L.J.,Hall, J. (deposition date: 2014-11-18, release date: 2015-11-11, Last modification date: 2023-09-27)
Primary citation	Hall, J.D.,Wang, H.,Byrnes, L.J.,Shanker, S.,Wang, K.,Efremov, I.V.,Chong, P.A.,Forman-Kay, J.D.,Aulabaugh, A.E. Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy. Protein Sci., 25:360-373, 2016 Cited by PubMed: 26444971 DOI: 10.1002/pro.2821 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation