4UU9
Crystal structure of the human c5a in complex with MEDI7814 a neutralising antibody
Summary for 4UU9
Entry DOI | 10.2210/pdb4uu9/pdb |
Descriptor | MEDI7814, COMPLEMENT C5, SULFATE ION, ... (5 entities in total) |
Functional Keywords | immune system, fv, complement system |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 6 |
Total formula weight | 67413.27 |
Authors | Colley, C.,Sridharan, S.,Dobson, C.,Popovic, B.,Debreczeni, J.E.,Hargreaves, D.,Edwards, B.,Brennan, J.,England, L.,Fung, S.,An Eghobamien, L.,Sivars, U.,Woods, R.,Flavell, L.,Renshaw, G.J.,Wickson, K.,Wilkinson, T.,Davies, R.,Bonnell, J.,Warrener, P.,Howes, R.,Vaughan, T. (deposition date: 2014-07-25, release date: 2015-08-12, Last modification date: 2019-02-27) |
Primary citation | Colley, C.S.,Popovic, B.,Sridharan, S.,Debreczeni, J.E.,Hargeaves, D.,Fung, M.,An, L.L.,Edwards, B.,Arnold, J.,England, E.,Eghobamien, L.,Sivars, U.,Flavell, L.,Renshaw, J.,Wickson, K.,Warrener, P.,Zha, J.,Bonnell, J.,Woods, R.,Wilkinson, T.,Dobson, C.,Vaughan, T.J. Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors. MAbs, 10:104-117, 2018 Cited by PubMed: 28952876DOI: 10.1080/19420862.2017.1384892 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.12 Å) |
Structure validation
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