4UU9

Crystal structure of the human c5a in complex with MEDI7814 a neutralising antibody

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0005576	cellular_component	extracellular region
C	0006954	biological_process	inflammatory response
C	0006956	biological_process	complement activation
D	0005576	cellular_component	extracellular region
D	0006954	biological_process	inflammatory response
D	0006956	biological_process	complement activation

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 H 1113

Chain	Residue
B	SER27
H	ARG71
H	ASP72
H	ASN73
H	SER74
H	HOH2044
H	HOH2085

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 L 1108

Chain	Residue
L	GLY68
L	LYS66
L	SER67

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 L 1109

Chain	Residue
L	GLN37
L	LYS45
L	ILE47
L	PHE62
L	HOH2042

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site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 1065

Chain	Residue
C	TYR13
C	LYS14
C	HIS15
C	VAL18
C	ARG46
C	HOH2012

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Functional Information from PROSITE/UniProt

site_id	PS01177
Number of Residues	35
Details	ANAPHYLATOXIN_1 Anaphylatoxin domain signature. CCydGacvnnde.TCEqraarisl.GprCikafte.CC

Chain	Residue	Details
C	CYS21-CYS55

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:18536718, ECO:0007744|PDB:3CU7, ECO:0007744|PDB:3KLS, ECO:0007744|PDB:3KM9

Chain	Residue	Details
C	ASN64
D	ASN64

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