4UU9
Crystal structure of the human c5a in complex with MEDI7814 a neutralising antibody
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006954 | biological_process | inflammatory response |
| C | 0006956 | biological_process | complement activation |
| D | 0005576 | cellular_component | extracellular region |
| D | 0006954 | biological_process | inflammatory response |
| D | 0006956 | biological_process | complement activation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 H 1113 |
| Chain | Residue |
| B | SER27 |
| H | ARG71 |
| H | ASP72 |
| H | ASN73 |
| H | SER74 |
| H | HOH2044 |
| H | HOH2085 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 L 1108 |
| Chain | Residue |
| L | GLY68 |
| L | LYS66 |
| L | SER67 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 L 1109 |
| Chain | Residue |
| L | GLN37 |
| L | LYS45 |
| L | ILE47 |
| L | PHE62 |
| L | HOH2042 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1065 |
| Chain | Residue |
| C | TYR13 |
| C | LYS14 |
| C | HIS15 |
| C | VAL18 |
| C | ARG46 |
| C | HOH2012 |
Functional Information from PROSITE/UniProt
| site_id | PS01177 |
| Number of Residues | 35 |
| Details | ANAPHYLATOXIN_1 Anaphylatoxin domain signature. CCydGacvnnde.TCEqraarisl.GprCikafte.CC |
| Chain | Residue | Details |
| C | CYS21-CYS55 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 68 |
| Details | Domain: {"description":"Anaphylatoxin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00022","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 58 |
| Details | Region: {"description":"Involved in C5AR1 binding","evidences":[{"source":"PubMed","id":"9553099","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18536718","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CU7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KLS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KM9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
