4UU9
Crystal structure of the human c5a in complex with MEDI7814 a neutralising antibody
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, H) | MEDI7814 | polymer | 123 | 13508.9 | 2 | HOMO SAPIENS (HUMAN) | ||
| 2 | B, F (B, L) | MEDI7814 | polymer | 111 | 11629.9 | 2 | HOMO SAPIENS (HUMAN) | ||
| 3 | C, D (C, D) | COMPLEMENT C5 | polymer | 75 | 8375.8 | 2 | UniProt (P01031) Pfam (PF01821) | HOMO SAPIENS (HUMAN) | C5A ANAPHYLATOXIN C5A, C3 AND PZP-LIKE ALPHA-2-MACROGLOBULIN DOMAIN-CONTAINING PROTEIN 4 |
| 4 | G, H, I, J (C, H, L) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 5 | K, L, M, N, O... (A, B, C, D, H...) | water | water | 18.0 | 301 | Chemie (HOH) |
Sequence modifications
C, D: 1 - 74 (UniProt: P01031)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 67029.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 384.3 | |
| All* | Total formula weight | 67413.3 |
