4UT9

Crystal structure of dengue 2 virus envelope glycoprotein dimer in complex with the ScFv fragment of the broadly neutralizing human antibody EDE1 C10

Summary for 4UT9

Entry DOI	10.2210/pdb4ut9/pdb
Related	4UT6 4UT7
Descriptor	ENVELOPE GLYCOPROTEIN E, BROADLY NEUTRALIZING HUMAN ANTIBODY EDE1 C10, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	immune system-viral protein complex, viral protein, membrane fusion, class 2 fusion protein, dengue virus, broadly neutralizing antibody, immune system, scfv fragment
Biological source	DENGUE VIRUS 2 More
Total number of polymer chains	12
Total formula weight	315056.76
Authors	Rouvinski, A.,Guardado-Calvo, P.,Barba-Spaeth, G.,Duquerroy, S.,Vaney, M.C.,Rey, F.A. (deposition date: 2014-07-18, release date: 2015-01-28, Last modification date: 2020-07-29)
Primary citation	Rouvinski, A.,Guardado-Calvo, P.,Barba-Spaeth, G.,Duquerroy, S.,Vaney, M.,Kikuti, C.M.,Sanchez, M.E.N.,Dejnirattisai, W.,Wongwiwat, W.,Haouz, A.,Girard-Blanc, C.,Petres, S.,Shepard, W.E.,Despres, P.,Arenzana-Seisdedos, F.,Dussart, P.,Mongkolsapaya, J.,Screaton, G.R.,Rey, F.A. Recognition Determinants of Broadly Neutralizing Human Antibodies Against Dengue Viruses. Nature, 520:109-, 2015 Cited by PubMed: 25581790 DOI: 10.1038/NATURE14130 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation