4UT9

Crystal structure of dengue 2 virus envelope glycoprotein dimer in complex with the ScFv fragment of the broadly neutralizing human antibody EDE1 C10

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	ENVELOPE GLYCOPROTEIN E	polymer	425	47231.0	4	UniProt (Q68Y26) Pfam (PF00869) Pfam (PF02832)	DENGUE VIRUS 2
2	E, F, G, H (H, I, J, K)	BROADLY NEUTRALIZING HUMAN ANTIBODY EDE1 C10	polymer	144	15679.2	4		HOMO SAPIENS (HUMAN)
3	I, J, K, L (L, M, N, O)	BROADLY NEUTRALIZING HUMAN ANTIBODY EDE1 C10	polymer	154	15632.8	4		HOMO SAPIENS (HUMAN)
4	M, N, O, P (A, B, C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)

Sequence modifications

A, B, C, D: 1 - 391 (UniProt: Q68Y26)

PDB	External Database	Details
Leu 1392	-	expression tag
Arg 1393	-	expression tag
Pro 1394	-	expression tag
Leu 1395	-	expression tag
Glu 1396	-	expression tag
Ser 1397	-	expression tag
Arg 1398	-	expression tag
Gly 1399	-	expression tag
Pro 1400	-	expression tag
Phe 1401	-	expression tag
Glu 1402	-	expression tag
Gly 1403	-	expression tag
Lys 1404	-	expression tag
Pro 1405	-	expression tag
Ile 1406	-	expression tag
Pro 1407	-	expression tag
Asn 1408	-	expression tag
Pro 1409	-	expression tag
Leu 1410	-	expression tag
Leu 1411	-	expression tag
Gly 1412	-	expression tag
Leu 1413	-	expression tag
Asp 1414	-	expression tag
Ser 1415	-	expression tag
Thr 1416	-	expression tag
Arg 1417	-	expression tag
Thr 1418	-	expression tag
Gly 1419	-	expression tag
His 1420	-	expression tag
His 1421	-	expression tag
His 1422	-	expression tag
His 1423	-	expression tag
His 1424	-	expression tag
His 1425	-	expression tag
Lys 118	Met 398	conflict

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	314171.9
Non-Polymers*	Number of molecules	4
	Total formula weight	884.8
All*	Total formula weight	315056.8

*Water molecules are not included.