4URM

Crystal Structure of Staph GyraseB 24kDa in complex with Kibdelomycin

Summary for 4URM

Entry DOI	10.2210/pdb4urm/pdb
Related	4URL 4URN 4URO
Descriptor	DNA GYRASE SUBUNIT B, (1R,4aS,5S,6S,8aR)-5-{[(5S)-1-(3-O-acetyl-4-O-carbamoyl-6-deoxy-2-O-methyl-alpha-L-talopyranosyl)-4-hydroxy-2-oxo-5-(propan-2-yl)-2,5-dihydro-1H-pyrrol-3-yl]carbonyl}-6-methyl-4-methylidene-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl 2,6-dideoxy-3-C-[(1S)-1-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}ethyl]-beta-D-ribo-hexopyranoside (3 entities in total)
Functional Keywords	isomerase, antibiotics, gyrase, topoisomerase iv, natural product
Biological source	STAPHYLOCOCCUS AUREUS
Cellular location	Cytoplasm (Potential): P0A0K8
Total number of polymer chains	4
Total formula weight	106513.96
Authors	Lu, J.,Patel, S.,Sharma, N.,Soisson, S.,Kishii, R.,Takei, M.,Fukuda, Y.,Lumb, K.J.,Singh, S.B. (deposition date: 2014-06-30, release date: 2014-07-30, Last modification date: 2014-10-01)
Primary citation	Lu, J.,Patel, S.,Sharma, N.,Soisson, S.M.,Kishii, R.,Takei, M.,Fukuda, Y.,Lumb, K.J.,Singh, S.B. Structures of Kibdelomycin Bound to Staphylococcus Aureus Gyrb and Pare Showed a Novel U-Shaped Binding Mode. Acs Chem.Biol., 9:2023-, 2014 Cited by PubMed: 24992706 DOI: 10.1021/CB5001197 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.94 Å)

Structure validation