4UM1
Engineered Ls-AChBP with alpha4-alpha4 binding pocket in complex with NS3573
Summary for 4UM1
Entry DOI | 10.2210/pdb4um1/pdb |
Related | 4UM3 |
Descriptor | ACETYLCHOLINE-BINDING PROTEIN, 1-(5-ethoxypyridin-3-yl)-1,4-diazepane, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | signaling protein, ion channel, receptor stoichiometry, cys-loop receptor, acetylcholine binding protein |
Biological source | LYMNAEA STAGNALIS (GREAT POND SNAIL) |
Cellular location | Secreted: P58154 |
Total number of polymer chains | 5 |
Total formula weight | 131593.42 |
Authors | Shahsavar, A.,Kastrup, J.S.,Balle, T.,Gajhede, M. (deposition date: 2014-05-14, release date: 2015-07-22, Last modification date: 2024-01-10) |
Primary citation | Shahsavar, A.,Ahring, P.K.,Olsen, J.A.,Krintel, C.,Kastrup, J.S.,Balle, T.,Gajhede, M. Achbp Engineered to Mimic the Alpha4-Alpha4 Binding Pocket in Alpha4Beta2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity Mol.Pharmacol., 88:697-, 2015 Cited by PubMed: 26180047DOI: 10.1124/MOL.115.098061 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.83 Å) |
Structure validation
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