4U79
Crystal structure of human JNK3 in complex with a benzenesulfonamide inhibitor.
Summary for 4U79
Entry DOI | 10.2210/pdb4u79/pdb |
Related | 3DA6 4U6R |
Descriptor | Mitogen-activated protein kinase 10, N-{4-[(3-{2-[(trans-4-aminocyclohexyl)amino]pyrimidin-4-yl}pyridin-2-yl)oxy]naphthalen-1-yl}benzenesulfonamide (3 entities in total) |
Functional Keywords | transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P53779 |
Total number of polymer chains | 1 |
Total formula weight | 42626.35 |
Authors | Mohr, C. (deposition date: 2014-07-30, release date: 2014-10-08, Last modification date: 2023-09-27) |
Primary citation | Harrington, P.E.,Biswas, K.,Malwitz, D.,Tasker, A.S.,Mohr, C.,Andrews, K.L.,Dellamaggiore, K.,Kendall, R.,Beckmann, H.,Jaeckel, P.,Materna-Reichelt, S.,Allen, J.R.,Lipford, J.R. Unfolded Protein Response in Cancer: IRE1 alpha Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability. Acs Med.Chem.Lett., 6:68-72, 2015 Cited by PubMed: 25589933DOI: 10.1021/ml500315b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.23 Å) |
Structure validation
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