4U6R
Crystal structure of human IRE1 cytoplasmic domains in complex with a sulfonamide inhibitor.
Summary for 4U6R
Entry DOI | 10.2210/pdb4u6r/pdb |
Related | 4U79 |
Descriptor | Serine/threonine-protein kinase/endoribonuclease IRE1, N-{4-[(3-{2-[(trans-4-aminocyclohexyl)amino]pyrimidin-4-yl}pyridin-2-yl)oxy]-3-methylnaphthalen-1-yl}-2-chlorobenzenesulfonamide, SULFATE ION, ... (6 entities in total) |
Functional Keywords | transferase, kinase, hydrolase, endoribonuclease, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Endoplasmic reticulum membrane ; Single-pass type I membrane protein : O75460 |
Total number of polymer chains | 1 |
Total formula weight | 53770.46 |
Authors | Mohr, C. (deposition date: 2014-07-29, release date: 2014-10-08, Last modification date: 2023-09-27) |
Primary citation | Harrington, P.E.,Biswas, K.,Malwitz, D.,Tasker, A.S.,Mohr, C.,Andrews, K.L.,Dellamaggiore, K.,Kendall, R.,Beckmann, H.,Jaeckel, P.,Materna-Reichelt, S.,Allen, J.R.,Lipford, J.R. Unfolded Protein Response in Cancer: IRE1 alpha Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability. Acs Med.Chem.Lett., 6:68-72, 2015 Cited by PubMed: 25589933DOI: 10.1021/ml500315b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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