4U58

IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR

Summary for 4U58

• Entry DOI: 10.2210/pdb4u58/pdb
• Descriptor: Importin subunit alpha-1, N~2~-[4-(pyridin-3-yl)benzoyl]-L-lysinamide (3 entities in total)
• Functional Keywords: tpx2 inhibitor, transport protein
• Biological source: Mus musculus (Mouse)
• Cellular location: Cytoplasm : P52293
• Total number of polymer chains: 1
• Total formula weight: 46470.22

Authors

Stewart, M.,Valkov, E.,Holvey, R.S. (deposition date: 2014-07-24, release date: 2015-05-13, Last modification date: 2015-07-08)

• Primary citation: Holvey, R.S.,Valkov, E.,Neal, D.,Stewart, M.,Abell, C.; Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.; Chemmedchem, 10:1232-1239, 2015; PubMed: 25899172; DOI: 10.1002/cmdc.201500014

Experimental method

X-RAY DIFFRACTION (2.56 Å)