4U15

M3-mT4L receptor bound to tiotropium

Summary for 4U15

• Entry DOI: 10.2210/pdb4u15/pdb
• Related: 4U14 4U16
• Descriptor: Muscarinic acetylcholine receptor M3,Lysozyme,Muscarinic acetylcholine receptor M3, (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, HEXAETHYLENE GLYCOL, ... (6 entities in total)
• Functional Keywords: gpcr t4l stabillized crystallography, membrane protein, membrane protein-inhibitor complex, membrane protein/inhibitor
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P08483
• Total number of polymer chains: 2
• Total formula weight: 98943.82

Authors

Thorsen, T.S.,Matt, R.,Weis, W.I.,Kobilka, B. (deposition date: 2014-07-15, release date: 2014-11-26, Last modification date: 2023-12-27)

• Primary citation: Thorsen, T.S.,Matt, R.,Weis, W.I.,Kobilka, B.K.; Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis.; Structure, 22:1657-1664, 2014; PubMed: 25450769; DOI: 10.1016/j.str.2014.08.022

Experimental method

X-RAY DIFFRACTION (2.8 Å)