4U14

Structure of the M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium crystallized with disulfide-stabilized T4 lysozyme (dsT4L)

Summary for 4U14

Entry DOI	10.2210/pdb4u14/pdb
Related	4U15 4U16
Descriptor	Muscarinic acetylcholine receptor M3,Endolysin,Muscarinic acetylcholine receptor M3, (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane (2 entities in total)
Functional Keywords	alpha helix, g protein-coupled receptors (gpcrs), membrane protein, t4 lysozyme, fusion protein, chimera protein
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	1
Total formula weight	53077.29
Authors	Thorsen, T.S.,Matt, R.A.,Weis, W.I.,Kobilka, B.K. (deposition date: 2014-07-15, release date: 2014-11-26, Last modification date: 2023-12-27)
Primary citation	Thorsen, T.S.,Matt, R.,Weis, W.I.,Kobilka, B.K. Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis. Structure, 22:1657-1664, 2014 Cited by PubMed: 25450769 DOI: 10.1016/j.str.2014.08.022 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.57 Å)

Structure validation