4U15
M3-mT4L receptor bound to tiotropium
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Muscarinic acetylcholine receptor M3,Lysozyme,Muscarinic acetylcholine receptor M3 | polymer | 418 | 47858.0 | 2 | UniProt (P08483) UniProt (D9IEF7) Pfam (PF00001) | Rattus norvegicus (Rat) | |
| 2 | C, I (A, B) | (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane | non-polymer | 392.5 | 2 | Chemie (0HK) PubChem (60831) PubChem (131951) PubChem (50909376) PubChem (123134303) PubChem (58667495) PubChem (59084585) PubChem (59168855) PubChem (59288009) PubChem (60003260) PubChem (87909275) PubChem (98047845) PubChem (122130800) PubChem (124527228) PubChem (656611) PubChem (3086655) PubChem (5487427) PubChem (5748851) PubChem (9804844) PubChem (11598033) PubChem (15057856) | |||
| 3 | D, E, F, L (A, B) | HEXAETHYLENE GLYCOL | non-polymer | 282.3 | 4 | Chemie (P6G) PubChem (17472) | |||
| 4 | G, H, M, N (A, B) | D(-)-TARTARIC ACID | non-polymer | 150.1 | 4 | Chemie (TAR) | |||
| 5 | J, K (B) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 2 | Chemie (OLC) PubChem (25021708) PubChem (54294270) PubChem (46840179) PubChem (33022) PubChem (54294271) PubChem (5283468) PubChem (5364833) PubChem (11451146) PubChem (12178130) | |||
| 6 | O (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A, B: 57 - 259 (UniProt: P08483)
A, B: 1018 - 1118 (UniProt: D9IEF7)
A, B: 482 - 563 (UniProt: P08483)
| PDB | External Database | Details |
|---|---|---|
| Gly 56 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 1054 | Cys 97 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 1001 | - | linker |
| Asn 1002 | - | linker |
| Ile 1003 | - | linker |
| Phe 1004 | - | linker |
| Glu 1005 | - | linker |
| Met 1006 | - | linker |
| Leu 1007 | - | linker |
| Arg 1008 | - | linker |
| Ile 1009 | - | linker |
| Asp 1010 | - | linker |
| Glu 1011 | - | linker |
| Gly 1012 | - | linker |
| Gly 1013 | - | linker |
| Gly 1014 | - | linker |
| Ser 1015 | - | linker |
| Gly 1016 | - | linker |
| Gly 1017 | - | linker |
| Lys 564 | - | expression tag |
| Arg 565 | - | expression tag |
| Lys 566 | - | expression tag |
| Arg 567 | - | expression tag |
| Arg 568 | - | expression tag |
| Lys 569 | - | expression tag |
| His 570 | - | expression tag |
| His 571 | - | expression tag |
| His 572 | - | expression tag |
| His 573 | - | expression tag |
| His 574 | - | expression tag |
| His 575 | - | expression tag |
| His 576 | - | expression tag |
| His 577 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 95716.0 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3227.8 | |
| All* | Total formula weight | 98943.8 |
