4TYH
Ternary complex of P38 and MK2 with a P38 inhibitor
Summary for 4TYH
Entry DOI | 10.2210/pdb4tyh/pdb |
Related | 4TYK |
Descriptor | MAP kinase-activated protein kinase 2, Mitogen-activated protein kinase 14, N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide, ... (4 entities in total) |
Functional Keywords | p38, mk2, p38 inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm : P49137 P47811 |
Total number of polymer chains | 2 |
Total formula weight | 80668.96 |
Authors | Cumming, J.G.,Debreczeni, J.E.,Edfeldt, F.,Evertsson, F.,Harrison, M.,Holdgate, G.,James, M.,Lamont, S.,Oldham, K.,Sullivan, J.E.,Wells, S. (deposition date: 2014-07-08, release date: 2015-07-22, Last modification date: 2023-12-27) |
Primary citation | Cumming, J.G. Discovery of substrate selective, ATP-competitive P38 alpha MAP kinase inhibitors To Be Published, |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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