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4TYH

Ternary complex of P38 and MK2 with a P38 inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0000077biological_processDNA damage checkpoint signaling
B0000165biological_processMAPK cascade
B0000166molecular_functionnucleotide binding
B0000902biological_processcell morphogenesis
B0000922cellular_componentspindle pole
B0001502biological_processcartilage condensation
B0001525biological_processangiogenesis
B0001649biological_processosteoblast differentiation
B0001890biological_processplacenta development
B0002021biological_processresponse to dietary excess
B0002062biological_processchondrocyte differentiation
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004707molecular_functionMAP kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006006biological_processglucose metabolic process
B0006355biological_processregulation of DNA-templated transcription
B0006357biological_processregulation of transcription by RNA polymerase II
B0006468biological_processprotein phosphorylation
B0006915biological_processapoptotic process
B0006974biological_processDNA damage response
B0007178biological_processcell surface receptor protein serine/threonine kinase signaling pathway
B0007519biological_processskeletal muscle tissue development
B0010628biological_processpositive regulation of gene expression
B0010831biological_processpositive regulation of myotube differentiation
B0016301molecular_functionkinase activity
B0016607cellular_componentnuclear speck
B0016740molecular_functiontransferase activity
B0019395biological_processfatty acid oxidation
B0019899molecular_functionenzyme binding
B0019903molecular_functionprotein phosphatase binding
B0030278biological_processregulation of ossification
B0030316biological_processosteoclast differentiation
B0031098biological_processstress-activated protein kinase signaling cascade
B0031663biological_processlipopolysaccharide-mediated signaling pathway
B0032495biological_processresponse to muramyl dipeptide
B0032496biological_processresponse to lipopolysaccharide
B0032735biological_processpositive regulation of interleukin-12 production
B0032868biological_processresponse to insulin
B0033209biological_processtumor necrosis factor-mediated signaling pathway
B0035331biological_processnegative regulation of hippo signaling
B0035556biological_processintracellular signal transduction
B0035924biological_processcellular response to vascular endothelial growth factor stimulus
B0035994biological_processresponse to muscle stretch
B0038066biological_processp38MAPK cascade
B0042307biological_processpositive regulation of protein import into nucleus
B0042770biological_processsignal transduction in response to DNA damage
B0045648biological_processpositive regulation of erythrocyte differentiation
B0045663biological_processpositive regulation of myoblast differentiation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046326biological_processpositive regulation of D-glucose import
B0048010biological_processvascular endothelial growth factor receptor signaling pathway
B0048273molecular_functionmitogen-activated protein kinase p38 binding
B0051146biological_processstriated muscle cell differentiation
B0051403biological_processstress-activated MAPK cascade
B0051525molecular_functionNFAT protein binding
B0051604biological_processprotein maturation
B0060043biological_processregulation of cardiac muscle cell proliferation
B0060045biological_processpositive regulation of cardiac muscle cell proliferation
B0060348biological_processbone development
B0070269biological_processpyroptotic inflammatory response
B0071222biological_processcellular response to lipopolysaccharide
B0071223biological_processcellular response to lipoteichoic acid
B0071356biological_processcellular response to tumor necrosis factor
B0071479biological_processcellular response to ionizing radiation
B0071493biological_processcellular response to UV-B
B0090090biological_processnegative regulation of canonical Wnt signaling pathway
B0090336biological_processpositive regulation of brown fat cell differentiation
B0090400biological_processstress-induced premature senescence
B0098586biological_processcellular response to virus
B0098978cellular_componentglutamatergic synapse
B0099179biological_processregulation of synaptic membrane adhesion
B0106310molecular_functionprotein serine kinase activity
B1900015biological_processregulation of cytokine production involved in inflammatory response
B1901741biological_processpositive regulation of myoblast fusion
B1904784biological_processNLRP1 inflammasome complex assembly
B2000379biological_processpositive regulation of reactive oxygen species metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue 39G B 401
ChainResidue
AGLN369
BLEU167
BASP168
BALA51
BLYS53
BGLU71
BLEU75
BTHR106
BHIS107
BMET109
BGLY110

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCaAfdtktghrv.........AVKK
ChainResidueDetails
BVAL30-LYS54
ALEU70-LYS93

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDVKpeNLLY
ChainResidueDetails
AILE182-TYR194

site_idPS01351
Number of Residues104
DetailsMAPK MAP kinase signature. FqsiihakrtyRElrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfliyqilrglkyihsadiih.........RDlKpsnlavnedC
ChainResidueDetails
BPHE59-CYS162

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues36
DetailsRegion: {"description":"Autoinhibitory helix","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues24
DetailsRegion: {"description":"p38 MAPK-binding site"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues9
DetailsMotif: {"description":"Nuclear export signal (NES)"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues3
DetailsMotif: {"description":"Bipartite nuclear localization signal 1"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues4
DetailsMotif: {"description":"Bipartite nuclear localization signal 2"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues1
DetailsActive site: {"description":"Proton acceptor"}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues2
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by MAPK14","evidences":[{"source":"PubMed","id":"8846784","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by MAPK14","evidences":[{"source":"PubMed","id":"8846784","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"21131586","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues1
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q16539","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q16539","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine; by ZAP70","evidences":[{"source":"UniProtKB","id":"Q16539","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

243911

PDB entries from 2025-10-29

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