4RCH
Discovery of 2-Pyridyl Ureas as Glucokinase Activators
Summary for 4RCH
Entry DOI | 10.2210/pdb4rch/pdb |
Related | 4MLE 4MLH |
Descriptor | Glucokinase, alpha-D-glucopyranose, 1-{3-[(2-ethylpyridin-3-yl)oxy]-5-(pyridin-2-ylsulfanyl)pyridin-2-yl}-3-methylurea, ... (4 entities in total) |
Functional Keywords | transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 53587.83 |
Authors | Voegtli, W.,Vigers, G.P.A. (deposition date: 2014-09-16, release date: 2014-10-08, Last modification date: 2023-09-20) |
Primary citation | Hinklin, R.J.,Aicher, T.D.,Anderson, D.A.,Baer, B.R.,Boyd, S.A.,Condroski, K.R.,DeWolf, W.E.,Kraser, C.F.,McVean, M.,Rhodes, S.P.,Sturgis, H.L.,Voegtli, W.C.,Williams, L.,Houze, J.B. Discovery of 2-pyridylureas as glucokinase activators. J.Med.Chem., 57:8180-8186, 2014 Cited by PubMed: 25203462DOI: 10.1021/jm501204z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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