4MLH

Human Glucokinase in Complex with a Novel Amino Thiazole Allosteric Activator

Summary for 4MLH

Entry DOI	10.2210/pdb4mlh/pdb
Related	4MLE
Descriptor	Glucokinase, alpha-D-glucopyranose, 3-(benzyloxy)-5-methyl-N-(4-methyl-1,3-thiazol-2-yl)pyridin-2-amine (3 entities in total)
Functional Keywords	sugar kinase, allosteric activator, small molecule, transferase-transferase activator complex, transferase/transferase activator
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	51500.55
Authors	Voegtli, W.C. (deposition date: 2013-09-06, release date: 2013-09-25, Last modification date: 2024-02-28)
Primary citation	Hinklin, R.J.,Boyd, S.A.,Chicarelli, M.J.,Condroski, K.R.,Dewolf, W.E.,Lee, P.A.,Lee, W.,Singh, A.,Thomas, L.,Voegtli, W.C.,Williams, L.,Aicher, T.D. Identification of a New Class of Glucokinase Activators through Structure-Based Design. J.Med.Chem., 56:7669-7678, 2013 Cited by PubMed: 24015910 DOI: 10.1021/jm401116k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation