4RCH
Discovery of 2-Pyridyl Ureas as Glucokinase Activators
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Glucokinase | polymer | 474 | 53026.2 | 1 | UniProt (P35557) Pfam (PF00349) Pfam (PF03727) In PDB | Homo sapiens (human) | Hexokinase type IV, HK IV, Hexokinase-4, HK4, Hexokinase-D |
2 | A | alpha-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (GLC) | |||
3 | A | 1-{3-[(2-ethylpyridin-3-yl)oxy]-5-(pyridin-2-ylsulfanyl)pyridin-2-yl}-3-methylurea | non-polymer | 381.5 | 1 | Chemie (3LZ) | |||
4 | water | water | 18.0 | 25 | Chemie (HOH) |
Sequence modifications
A: 16 - 465 (UniProt: P35557)
PDB | External Database | Details |
---|---|---|
Met -8 | - | expression tag |
Ser -7 | - | expression tag |
Gly -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
Ala 1 | - | expression tag |
Ser 2 | - | expression tag |
Ser 3 | - | expression tag |
Gly 4 | - | expression tag |
Leu 5 | - | expression tag |
Val 6 | - | expression tag |
Pro 7 | - | expression tag |
Arg 8 | - | expression tag |
Gly 9 | - | expression tag |
Ser 10 | - | expression tag |
Met 11 | - | expression tag |
Ala 12 | - | expression tag |
Leu 13 | - | expression tag |
Thr 14 | - | expression tag |
Leu 15 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 53026.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 561.6 | |
All* | Total formula weight | 53587.8 |