4QXW
Crystal structure of the human CEACAM1 membrane distal amino terminal (N)-domain
Summary for 4QXW
Entry DOI | 10.2210/pdb4qxw/pdb |
Related | 2GK2 4QYC |
Descriptor | Carcinoembryonic antigen-related cell adhesion molecule 1, MALONIC ACID, octyl beta-D-glucopyranoside, ... (4 entities in total) |
Functional Keywords | cell adhesion |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Secreted. Isoform 4: Secreted. Isoform 5: Cell membrane; Single-pass type I membrane protein. Isoform 6: Cell membrane; Single-pass type I membrane protein. Isoform 7: Cell membrane; Single-pass type I membrane protein. Isoform 8: Cell membrane; Single-pass type I membrane protein: P13688 |
Total number of polymer chains | 2 |
Total formula weight | 24487.14 |
Authors | Huang, Y.H.,Gandhi, A.K.,Russell, A.,Kondo, Y.,Chen, Q.,Petsko, G.A.,Blumberg, R.S. (deposition date: 2014-07-22, release date: 2014-11-12, Last modification date: 2024-02-28) |
Primary citation | Huang, Y.H.,Zhu, C.,Kondo, Y.,Anderson, A.C.,Gandhi, A.,Russell, A.,Dougan, S.K.,Petersen, B.S.,Melum, E.,Pertel, T.,Clayton, K.L.,Raab, M.,Chen, Q.,Beauchemin, N.,Yazaki, P.J.,Pyzik, M.,Ostrowski, M.A.,Glickman, J.N.,Rudd, C.E.,Ploegh, H.L.,Franke, A.,Petsko, G.A.,Kuchroo, V.K.,Blumberg, R.S. CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature, 517:386-390, 2015 Cited by PubMed: 25363763DOI: 10.1038/nature13848 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
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