4QNQ
Crystal Structure Analysis of full-length Bcl-XL in complex with the inhibitor ABT-263
Summary for 4QNQ
Entry DOI | 10.2210/pdb4qnq/pdb |
Descriptor | Bcl-2-like protein 1, 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]benzamide (3 entities in total) |
Functional Keywords | alpha-helical protein, apoptosis, apoptosis-apoptosis inhibitor complex, apoptosis/apoptosis inhibitor |
Biological source | Rattus norvegicus (rat) |
Cellular location | Isoform Bcl-X(L): Mitochondrion inner membrane: P53563 |
Total number of polymer chains | 12 |
Total formula weight | 333951.32 |
Authors | Korste, A.,Vetter, I.R.,Stoll, R. (deposition date: 2014-06-18, release date: 2015-10-28, Last modification date: 2023-09-20) |
Primary citation | Korste, A.,Vetter, I.R.,Stoll, R. Crystal Structure Analysis of full-length Bcl-XL in complex with the inhibitor ABT-263 TO BE PUBLISHED, |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report