4QNQ

Crystal Structure Analysis of full-length Bcl-XL in complex with the inhibitor ABT-263

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001541	biological_process	ovarian follicle development
A	0001666	biological_process	response to hypoxia
A	0001836	biological_process	release of cytochrome c from mitochondria
A	0002931	biological_process	response to ischemia
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005743	cellular_component	mitochondrial inner membrane
A	0005759	cellular_component	mitochondrial matrix
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0005905	cellular_component	clathrin-coated pit
A	0006950	biological_process	response to stress
A	0006979	biological_process	response to oxidative stress
A	0008021	cellular_component	synaptic vesicle
A	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
A	0009410	biological_process	response to xenobiotic stimulus
A	0010288	biological_process	response to lead ion
A	0015267	molecular_function	channel activity
A	0016020	cellular_component	membrane
A	0021987	biological_process	cerebral cortex development
A	0030276	molecular_function	clathrin binding
A	0030672	cellular_component	synaptic vesicle membrane
A	0031965	cellular_component	nuclear membrane
A	0031966	cellular_component	mitochondrial membrane
A	0032465	biological_process	regulation of cytokinesis
A	0032496	biological_process	response to lipopolysaccharide
A	0034976	biological_process	response to endoplasmic reticulum stress
A	0036017	biological_process	response to erythropoietin
A	0036018	biological_process	cellular response to erythropoietin
A	0036466	biological_process	synaptic vesicle recycling via endosome
A	0042542	biological_process	response to hydrogen peroxide
A	0042981	biological_process	regulation of apoptotic process
A	0043027	molecular_function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
A	0043065	biological_process	positive regulation of apoptotic process
A	0043066	biological_process	negative regulation of apoptotic process
A	0043434	biological_process	response to peptide hormone
A	0044877	molecular_function	protein-containing complex binding
A	0051020	molecular_function	GTPase binding
A	0051400	molecular_function	BH domain binding
A	0051602	biological_process	response to electrical stimulus
A	0051707	biological_process	response to other organism
A	0055085	biological_process	transmembrane transport
A	0071320	biological_process	cellular response to cAMP
A	0071347	biological_process	cellular response to interleukin-1
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0071456	biological_process	cellular response to hypoxia
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	0071549	biological_process	cellular response to dexamethasone stimulus
A	0071732	biological_process	cellular response to nitric oxide
A	0072347	biological_process	response to anesthetic
A	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
A	0097371	molecular_function	MDM2/MDM4 family protein binding
A	0098793	cellular_component	presynapse
A	1900118	biological_process	negative regulation of execution phase of apoptosis
A	1900242	biological_process	regulation of synaptic vesicle endocytosis
A	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
A	1900452	biological_process	regulation of long-term synaptic depression
A	1901654	biological_process	response to ketone
A	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
A	1905218	biological_process	cellular response to astaxanthin
A	1990646	biological_process	cellular response to prolactin
A	2000809	biological_process	positive regulation of synaptic vesicle clustering
B	0001541	biological_process	ovarian follicle development
B	0001666	biological_process	response to hypoxia
B	0001836	biological_process	release of cytochrome c from mitochondria
B	0002931	biological_process	response to ischemia
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005743	cellular_component	mitochondrial inner membrane
B	0005759	cellular_component	mitochondrial matrix
B	0005813	cellular_component	centrosome
B	0005829	cellular_component	cytosol
B	0005905	cellular_component	clathrin-coated pit
B	0006950	biological_process	response to stress
B	0006979	biological_process	response to oxidative stress
B	0008021	cellular_component	synaptic vesicle
B	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
B	0009410	biological_process	response to xenobiotic stimulus
B	0010288	biological_process	response to lead ion
B	0015267	molecular_function	channel activity
B	0016020	cellular_component	membrane
B	0021987	biological_process	cerebral cortex development
B	0030276	molecular_function	clathrin binding
B	0030672	cellular_component	synaptic vesicle membrane
B	0031965	cellular_component	nuclear membrane
B	0031966	cellular_component	mitochondrial membrane
B	0032465	biological_process	regulation of cytokinesis
B	0032496	biological_process	response to lipopolysaccharide
B	0034976	biological_process	response to endoplasmic reticulum stress
B	0036017	biological_process	response to erythropoietin
B	0036018	biological_process	cellular response to erythropoietin
B	0036466	biological_process	synaptic vesicle recycling via endosome
B	0042542	biological_process	response to hydrogen peroxide
B	0042981	biological_process	regulation of apoptotic process
B	0043027	molecular_function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
B	0043065	biological_process	positive regulation of apoptotic process
B	0043066	biological_process	negative regulation of apoptotic process
B	0043434	biological_process	response to peptide hormone
B	0044877	molecular_function	protein-containing complex binding
B	0051020	molecular_function	GTPase binding
B	0051400	molecular_function	BH domain binding
B	0051602	biological_process	response to electrical stimulus
B	0051707	biological_process	response to other organism
B	0055085	biological_process	transmembrane transport
B	0071320	biological_process	cellular response to cAMP
B	0071347	biological_process	cellular response to interleukin-1
B	0071356	biological_process	cellular response to tumor necrosis factor
B	0071456	biological_process	cellular response to hypoxia
B	0071466	biological_process	cellular response to xenobiotic stimulus
B	0071549	biological_process	cellular response to dexamethasone stimulus
B	0071732	biological_process	cellular response to nitric oxide
B	0072347	biological_process	response to anesthetic
B	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
B	0097371	molecular_function	MDM2/MDM4 family protein binding
B	0098793	cellular_component	presynapse
B	1900118	biological_process	negative regulation of execution phase of apoptosis
B	1900242	biological_process	regulation of synaptic vesicle endocytosis
B	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
B	1900452	biological_process	regulation of long-term synaptic depression
B	1901654	biological_process	response to ketone
B	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
B	1905218	biological_process	cellular response to astaxanthin
B	1990646	biological_process	cellular response to prolactin
B	2000809	biological_process	positive regulation of synaptic vesicle clustering
C	0001541	biological_process	ovarian follicle development
C	0001666	biological_process	response to hypoxia
C	0001836	biological_process	release of cytochrome c from mitochondria
C	0002931	biological_process	response to ischemia
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005741	cellular_component	mitochondrial outer membrane
C	0005743	cellular_component	mitochondrial inner membrane
C	0005759	cellular_component	mitochondrial matrix
C	0005813	cellular_component	centrosome
C	0005829	cellular_component	cytosol
C	0005905	cellular_component	clathrin-coated pit
C	0006950	biological_process	response to stress
C	0006979	biological_process	response to oxidative stress
C	0008021	cellular_component	synaptic vesicle
C	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
C	0009410	biological_process	response to xenobiotic stimulus
C	0010288	biological_process	response to lead ion
C	0015267	molecular_function	channel activity
C	0016020	cellular_component	membrane
C	0021987	biological_process	cerebral cortex development
C	0030276	molecular_function	clathrin binding
C	0030672	cellular_component	synaptic vesicle membrane
C	0031965	cellular_component	nuclear membrane
C	0031966	cellular_component	mitochondrial membrane
C	0032465	biological_process	regulation of cytokinesis
C	0032496	biological_process	response to lipopolysaccharide
C	0034976	biological_process	response to endoplasmic reticulum stress
C	0036017	biological_process	response to erythropoietin
C	0036018	biological_process	cellular response to erythropoietin
C	0036466	biological_process	synaptic vesicle recycling via endosome
C	0042542	biological_process	response to hydrogen peroxide
C	0042981	biological_process	regulation of apoptotic process
C	0043027	molecular_function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
C	0043065	biological_process	positive regulation of apoptotic process
C	0043066	biological_process	negative regulation of apoptotic process
C	0043434	biological_process	response to peptide hormone
C	0044877	molecular_function	protein-containing complex binding
C	0051020	molecular_function	GTPase binding
C	0051400	molecular_function	BH domain binding
C	0051602	biological_process	response to electrical stimulus
C	0051707	biological_process	response to other organism
C	0055085	biological_process	transmembrane transport
C	0071320	biological_process	cellular response to cAMP
C	0071347	biological_process	cellular response to interleukin-1
C	0071356	biological_process	cellular response to tumor necrosis factor
C	0071456	biological_process	cellular response to hypoxia
C	0071466	biological_process	cellular response to xenobiotic stimulus
C	0071549	biological_process	cellular response to dexamethasone stimulus
C	0071732	biological_process	cellular response to nitric oxide
C	0072347	biological_process	response to anesthetic
C	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
C	0097371	molecular_function	MDM2/MDM4 family protein binding
C	0098793	cellular_component	presynapse
C	1900118	biological_process	negative regulation of execution phase of apoptosis
C	1900242	biological_process	regulation of synaptic vesicle endocytosis
C	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
C	1900452	biological_process	regulation of long-term synaptic depression
C	1901654	biological_process	response to ketone
C	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
C	1905218	biological_process	cellular response to astaxanthin
C	1990646	biological_process	cellular response to prolactin
C	2000809	biological_process	positive regulation of synaptic vesicle clustering
D	0001541	biological_process	ovarian follicle development
D	0001666	biological_process	response to hypoxia
D	0001836	biological_process	release of cytochrome c from mitochondria
D	0002931	biological_process	response to ischemia
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005741	cellular_component	mitochondrial outer membrane
D	0005743	cellular_component	mitochondrial inner membrane
D	0005759	cellular_component	mitochondrial matrix
D	0005813	cellular_component	centrosome
D	0005829	cellular_component	cytosol
D	0005905	cellular_component	clathrin-coated pit
D	0006950	biological_process	response to stress
D	0006979	biological_process	response to oxidative stress
D	0008021	cellular_component	synaptic vesicle
D	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
D	0009410	biological_process	response to xenobiotic stimulus
D	0010288	biological_process	response to lead ion
D	0015267	molecular_function	channel activity
D	0016020	cellular_component	membrane
D	0021987	biological_process	cerebral cortex development
D	0030276	molecular_function	clathrin binding
D	0030672	cellular_component	synaptic vesicle membrane
D	0031965	cellular_component	nuclear membrane
D	0031966	cellular_component	mitochondrial membrane
D	0032465	biological_process	regulation of cytokinesis
D	0032496	biological_process	response to lipopolysaccharide
D	0034976	biological_process	response to endoplasmic reticulum stress
D	0036017	biological_process	response to erythropoietin
D	0036018	biological_process	cellular response to erythropoietin
D	0036466	biological_process	synaptic vesicle recycling via endosome
D	0042542	biological_process	response to hydrogen peroxide
D	0042981	biological_process	regulation of apoptotic process
D	0043027	molecular_function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
D	0043065	biological_process	positive regulation of apoptotic process
D	0043066	biological_process	negative regulation of apoptotic process
D	0043434	biological_process	response to peptide hormone
D	0044877	molecular_function	protein-containing complex binding
D	0051020	molecular_function	GTPase binding
D	0051400	molecular_function	BH domain binding
D	0051602	biological_process	response to electrical stimulus
D	0051707	biological_process	response to other organism
D	0055085	biological_process	transmembrane transport
D	0071320	biological_process	cellular response to cAMP
D	0071347	biological_process	cellular response to interleukin-1
D	0071356	biological_process	cellular response to tumor necrosis factor
D	0071456	biological_process	cellular response to hypoxia
D	0071466	biological_process	cellular response to xenobiotic stimulus
D	0071549	biological_process	cellular response to dexamethasone stimulus
D	0071732	biological_process	cellular response to nitric oxide
D	0072347	biological_process	response to anesthetic
D	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
D	0097371	molecular_function	MDM2/MDM4 family protein binding
D	0098793	cellular_component	presynapse
D	1900118	biological_process	negative regulation of execution phase of apoptosis
D	1900242	biological_process	regulation of synaptic vesicle endocytosis
D	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
D	1900452	biological_process	regulation of long-term synaptic depression
D	1901654	biological_process	response to ketone
D	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
D	1905218	biological_process	cellular response to astaxanthin
D	1990646	biological_process	cellular response to prolactin
D	2000809	biological_process	positive regulation of synaptic vesicle clustering
E	0001541	biological_process	ovarian follicle development
E	0001666	biological_process	response to hypoxia
E	0001836	biological_process	release of cytochrome c from mitochondria
E	0002931	biological_process	response to ischemia
E	0005515	molecular_function	protein binding
E	0005739	cellular_component	mitochondrion
E	0005741	cellular_component	mitochondrial outer membrane
E	0005743	cellular_component	mitochondrial inner membrane
E	0005759	cellular_component	mitochondrial matrix
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005905	cellular_component	clathrin-coated pit
E	0006950	biological_process	response to stress
E	0006979	biological_process	response to oxidative stress
E	0008021	cellular_component	synaptic vesicle
E	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
E	0009410	biological_process	response to xenobiotic stimulus
E	0010288	biological_process	response to lead ion
E	0015267	molecular_function	channel activity
E	0016020	cellular_component	membrane
E	0021987	biological_process	cerebral cortex development
E	0030276	molecular_function	clathrin binding
E	0030672	cellular_component	synaptic vesicle membrane
E	0031965	cellular_component	nuclear membrane
E	0031966	cellular_component	mitochondrial membrane
E	0032465	biological_process	regulation of cytokinesis
E	0032496	biological_process	response to lipopolysaccharide
E	0034976	biological_process	response to endoplasmic reticulum stress
E	0036017	biological_process	response to erythropoietin
E	0036018	biological_process	cellular response to erythropoietin
E	0036466	biological_process	synaptic vesicle recycling via endosome
E	0042542	biological_process	response to hydrogen peroxide
E	0042981	biological_process	regulation of apoptotic process
E	0043027	molecular_function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
E	0043065	biological_process	positive regulation of apoptotic process
E	0043066	biological_process	negative regulation of apoptotic process
E	0043434	biological_process	response to peptide hormone
E	0044877	molecular_function	protein-containing complex binding
E	0051020	molecular_function	GTPase binding
E	0051400	molecular_function	BH domain binding
E	0051602	biological_process	response to electrical stimulus
E	0051707	biological_process	response to other organism
E	0055085	biological_process	transmembrane transport
E	0071320	biological_process	cellular response to cAMP
E	0071347	biological_process	cellular response to interleukin-1
E	0071356	biological_process	cellular response to tumor necrosis factor
E	0071456	biological_process	cellular response to hypoxia
E	0071466	biological_process	cellular response to xenobiotic stimulus
E	0071549	biological_process	cellular response to dexamethasone stimulus
E	0071732	biological_process	cellular response to nitric oxide
E	0072347	biological_process	response to anesthetic
E	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
E	0097371	molecular_function	MDM2/MDM4 family protein binding
E	0098793	cellular_component	presynapse
E	1900118	biological_process	negative regulation of execution phase of apoptosis
E	1900242	biological_process	regulation of synaptic vesicle endocytosis
E	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
E	1900452	biological_process	regulation of long-term synaptic depression
E	1901654	biological_process	response to ketone
E	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
E	1905218	biological_process	cellular response to astaxanthin
E	1990646	biological_process	cellular response to prolactin
E	2000809	biological_process	positive regulation of synaptic vesicle clustering
F	0001541	biological_process	ovarian follicle development
F	0001666	biological_process	response to hypoxia
F	0001836	biological_process	release of cytochrome c from mitochondria
F	0002931	biological_process	response to ischemia
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005741	cellular_component	mitochondrial outer membrane
F	0005743	cellular_component	mitochondrial inner membrane
F	0005759	cellular_component	mitochondrial matrix
F	0005813	cellular_component	centrosome
F	0005829	cellular_component	cytosol
F	0005905	cellular_component	clathrin-coated pit
F	0006950	biological_process	response to stress
F	0006979	biological_process	response to oxidative stress
F	0008021	cellular_component	synaptic vesicle
F	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
F	0009410	biological_process	response to xenobiotic stimulus
F	0010288	biological_process	response to lead ion
F	0015267	molecular_function	channel activity
F	0016020	cellular_component	membrane
F	0021987	biological_process	cerebral cortex development
F	0030276	molecular_function	clathrin binding
F	0030672	cellular_component	synaptic vesicle membrane
F	0031965	cellular_component	nuclear membrane
F	0031966	cellular_component	mitochondrial membrane
F	0032465	biological_process	regulation of cytokinesis
F	0032496	biological_process	response to lipopolysaccharide
F	0034976	biological_process	response to endoplasmic reticulum stress
F	0036017	biological_process	response to erythropoietin
F	0036018	biological_process	cellular response to erythropoietin
F	0036466	biological_process	synaptic vesicle recycling via endosome
F	0042542	biological_process	response to hydrogen peroxide
F	0042981	biological_process	regulation of apoptotic process
F	0043027	molecular_function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
F	0043065	biological_process	positive regulation of apoptotic process
F	0043066	biological_process	negative regulation of apoptotic process
F	0043434	biological_process	response to peptide hormone
F	0044877	molecular_function	protein-containing complex binding
F	0051020	molecular_function	GTPase binding
F	0051400	molecular_function	BH domain binding
F	0051602	biological_process	response to electrical stimulus
F	0051707	biological_process	response to other organism
F	0055085	biological_process	transmembrane transport
F	0071320	biological_process	cellular response to cAMP
F	0071347	biological_process	cellular response to interleukin-1
F	0071356	biological_process	cellular response to tumor necrosis factor
F	0071456	biological_process	cellular response to hypoxia
F	0071466	biological_process	cellular response to xenobiotic stimulus
F	0071549	biological_process	cellular response to dexamethasone stimulus
F	0071732	biological_process	cellular response to nitric oxide
F	0072347	biological_process	response to anesthetic
F	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
F	0097371	molecular_function	MDM2/MDM4 family protein binding
F	0098793	cellular_component	presynapse
F	1900118	biological_process	negative regulation of execution phase of apoptosis
F	1900242	biological_process	regulation of synaptic vesicle endocytosis
F	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
F	1900452	biological_process	regulation of long-term synaptic depression
F	1901654	biological_process	response to ketone
F	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
F	1905218	biological_process	cellular response to astaxanthin
F	1990646	biological_process	cellular response to prolactin
F	2000809	biological_process	positive regulation of synaptic vesicle clustering
G	0001541	biological_process	ovarian follicle development
G	0001666	biological_process	response to hypoxia
G	0001836	biological_process	release of cytochrome c from mitochondria
G	0002931	biological_process	response to ischemia
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005741	cellular_component	mitochondrial outer membrane
G	0005743	cellular_component	mitochondrial inner membrane
G	0005759	cellular_component	mitochondrial matrix
G	0005813	cellular_component	centrosome
G	0005829	cellular_component	cytosol
G	0005905	cellular_component	clathrin-coated pit
G	0006950	biological_process	response to stress
G	0006979	biological_process	response to oxidative stress
G	0008021	cellular_component	synaptic vesicle
G	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
G	0009410	biological_process	response to xenobiotic stimulus
G	0010288	biological_process	response to lead ion
G	0015267	molecular_function	channel activity
G	0016020	cellular_component	membrane
G	0021987	biological_process	cerebral cortex development
G	0030276	molecular_function	clathrin binding
G	0030672	cellular_component	synaptic vesicle membrane
G	0031965	cellular_component	nuclear membrane
G	0031966	cellular_component	mitochondrial membrane
G	0032465	biological_process	regulation of cytokinesis
G	0032496	biological_process	response to lipopolysaccharide
G	0034976	biological_process	response to endoplasmic reticulum stress
G	0036017	biological_process	response to erythropoietin
G	0036018	biological_process	cellular response to erythropoietin
G	0036466	biological_process	synaptic vesicle recycling via endosome
G	0042542	biological_process	response to hydrogen peroxide
G	0042981	biological_process	regulation of apoptotic process
G	0043027	molecular_function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
G	0043065	biological_process	positive regulation of apoptotic process
G	0043066	biological_process	negative regulation of apoptotic process
G	0043434	biological_process	response to peptide hormone
G	0044877	molecular_function	protein-containing complex binding
G	0051020	molecular_function	GTPase binding
G	0051400	molecular_function	BH domain binding
G	0051602	biological_process	response to electrical stimulus
G	0051707	biological_process	response to other organism
G	0055085	biological_process	transmembrane transport
G	0071320	biological_process	cellular response to cAMP
G	0071347	biological_process	cellular response to interleukin-1
G	0071356	biological_process	cellular response to tumor necrosis factor
G	0071456	biological_process	cellular response to hypoxia
G	0071466	biological_process	cellular response to xenobiotic stimulus
G	0071549	biological_process	cellular response to dexamethasone stimulus
G	0071732	biological_process	cellular response to nitric oxide
G	0072347	biological_process	response to anesthetic
G	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
G	0097371	molecular_function	MDM2/MDM4 family protein binding
G	0098793	cellular_component	presynapse
G	1900118	biological_process	negative regulation of execution phase of apoptosis
G	1900242	biological_process	regulation of synaptic vesicle endocytosis
G	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
G	1900452	biological_process	regulation of long-term synaptic depression
G	1901654	biological_process	response to ketone
G	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
G	1905218	biological_process	cellular response to astaxanthin
G	1990646	biological_process	cellular response to prolactin
G	2000809	biological_process	positive regulation of synaptic vesicle clustering
H	0001541	biological_process	ovarian follicle development
H	0001666	biological_process	response to hypoxia
H	0001836	biological_process	release of cytochrome c from mitochondria
H	0002931	biological_process	response to ischemia
H	0005515	molecular_function	protein binding
H	0005739	cellular_component	mitochondrion
H	0005741	cellular_component	mitochondrial outer membrane
H	0005743	cellular_component	mitochondrial inner membrane
H	0005759	cellular_component	mitochondrial matrix
H	0005813	cellular_component	centrosome
H	0005829	cellular_component	cytosol
H	0005905	cellular_component	clathrin-coated pit
H	0006950	biological_process	response to stress
H	0006979	biological_process	response to oxidative stress
H	0008021	cellular_component	synaptic vesicle
H	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
H	0009410	biological_process	response to xenobiotic stimulus
H	0010288	biological_process	response to lead ion
H	0015267	molecular_function	channel activity
H	0016020	cellular_component	membrane
H	0021987	biological_process	cerebral cortex development
H	0030276	molecular_function	clathrin binding
H	0030672	cellular_component	synaptic vesicle membrane
H	0031965	cellular_component	nuclear membrane
H	0031966	cellular_component	mitochondrial membrane
H	0032465	biological_process	regulation of cytokinesis
H	0032496	biological_process	response to lipopolysaccharide
H	0034976	biological_process	response to endoplasmic reticulum stress
H	0036017	biological_process	response to erythropoietin
H	0036018	biological_process	cellular response to erythropoietin
H	0036466	biological_process	synaptic vesicle recycling via endosome
H	0042542	biological_process	response to hydrogen peroxide
H	0042981	biological_process	regulation of apoptotic process
H	0043027	molecular_function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
H	0043065	biological_process	positive regulation of apoptotic process
H	0043066	biological_process	negative regulation of apoptotic process
H	0043434	biological_process	response to peptide hormone
H	0044877	molecular_function	protein-containing complex binding
H	0051020	molecular_function	GTPase binding
H	0051400	molecular_function	BH domain binding
H	0051602	biological_process	response to electrical stimulus
H	0051707	biological_process	response to other organism
H	0055085	biological_process	transmembrane transport
H	0071320	biological_process	cellular response to cAMP
H	0071347	biological_process	cellular response to interleukin-1
H	0071356	biological_process	cellular response to tumor necrosis factor
H	0071456	biological_process	cellular response to hypoxia
H	0071466	biological_process	cellular response to xenobiotic stimulus
H	0071549	biological_process	cellular response to dexamethasone stimulus
H	0071732	biological_process	cellular response to nitric oxide
H	0072347	biological_process	response to anesthetic
H	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
H	0097371	molecular_function	MDM2/MDM4 family protein binding
H	0098793	cellular_component	presynapse
H	1900118	biological_process	negative regulation of execution phase of apoptosis
H	1900242	biological_process	regulation of synaptic vesicle endocytosis
H	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
H	1900452	biological_process	regulation of long-term synaptic depression
H	1901654	biological_process	response to ketone
H	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
H	1905218	biological_process	cellular response to astaxanthin
H	1990646	biological_process	cellular response to prolactin
H	2000809	biological_process	positive regulation of synaptic vesicle clustering
I	0001541	biological_process	ovarian follicle development
I	0001666	biological_process	response to hypoxia
I	0001836	biological_process	release of cytochrome c from mitochondria
I	0002931	biological_process	response to ischemia
I	0005515	molecular_function	protein binding
I	0005739	cellular_component	mitochondrion
I	0005741	cellular_component	mitochondrial outer membrane
I	0005743	cellular_component	mitochondrial inner membrane
I	0005759	cellular_component	mitochondrial matrix
I	0005813	cellular_component	centrosome
I	0005829	cellular_component	cytosol
I	0005905	cellular_component	clathrin-coated pit
I	0006950	biological_process	response to stress
I	0006979	biological_process	response to oxidative stress
I	0008021	cellular_component	synaptic vesicle
I	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
I	0009410	biological_process	response to xenobiotic stimulus
I	0010288	biological_process	response to lead ion
I	0015267	molecular_function	channel activity
I	0016020	cellular_component	membrane
I	0021987	biological_process	cerebral cortex development
I	0030276	molecular_function	clathrin binding
I	0030672	cellular_component	synaptic vesicle membrane
I	0031965	cellular_component	nuclear membrane
I	0031966	cellular_component	mitochondrial membrane
I	0032465	biological_process	regulation of cytokinesis
I	0032496	biological_process	response to lipopolysaccharide
I	0034976	biological_process	response to endoplasmic reticulum stress
I	0036017	biological_process	response to erythropoietin
I	0036018	biological_process	cellular response to erythropoietin
I	0036466	biological_process	synaptic vesicle recycling via endosome
I	0042542	biological_process	response to hydrogen peroxide
I	0042981	biological_process	regulation of apoptotic process
I	0043027	molecular_function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
I	0043065	biological_process	positive regulation of apoptotic process
I	0043066	biological_process	negative regulation of apoptotic process
I	0043434	biological_process	response to peptide hormone
I	0044877	molecular_function	protein-containing complex binding
I	0051020	molecular_function	GTPase binding
I	0051400	molecular_function	BH domain binding
I	0051602	biological_process	response to electrical stimulus
I	0051707	biological_process	response to other organism
I	0055085	biological_process	transmembrane transport
I	0071320	biological_process	cellular response to cAMP
I	0071347	biological_process	cellular response to interleukin-1
I	0071356	biological_process	cellular response to tumor necrosis factor
I	0071456	biological_process	cellular response to hypoxia
I	0071466	biological_process	cellular response to xenobiotic stimulus
I	0071549	biological_process	cellular response to dexamethasone stimulus
I	0071732	biological_process	cellular response to nitric oxide
I	0072347	biological_process	response to anesthetic
I	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
I	0097371	molecular_function	MDM2/MDM4 family protein binding
I	0098793	cellular_component	presynapse
I	1900118	biological_process	negative regulation of execution phase of apoptosis
I	1900242	biological_process	regulation of synaptic vesicle endocytosis
I	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
I	1900452	biological_process	regulation of long-term synaptic depression
I	1901654	biological_process	response to ketone
I	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
I	1905218	biological_process	cellular response to astaxanthin
I	1990646	biological_process	cellular response to prolactin
I	2000809	biological_process	positive regulation of synaptic vesicle clustering
J	0001541	biological_process	ovarian follicle development
J	0001666	biological_process	response to hypoxia
J	0001836	biological_process	release of cytochrome c from mitochondria
J	0002931	biological_process	response to ischemia
J	0005515	molecular_function	protein binding
J	0005739	cellular_component	mitochondrion
J	0005741	cellular_component	mitochondrial outer membrane
J	0005743	cellular_component	mitochondrial inner membrane
J	0005759	cellular_component	mitochondrial matrix
J	0005813	cellular_component	centrosome
J	0005829	cellular_component	cytosol
J	0005905	cellular_component	clathrin-coated pit
J	0006950	biological_process	response to stress
J	0006979	biological_process	response to oxidative stress
J	0008021	cellular_component	synaptic vesicle
J	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
J	0009410	biological_process	response to xenobiotic stimulus
J	0010288	biological_process	response to lead ion
J	0015267	molecular_function	channel activity
J	0016020	cellular_component	membrane
J	0021987	biological_process	cerebral cortex development
J	0030276	molecular_function	clathrin binding
J	0030672	cellular_component	synaptic vesicle membrane
J	0031965	cellular_component	nuclear membrane
J	0031966	cellular_component	mitochondrial membrane
J	0032465	biological_process	regulation of cytokinesis
J	0032496	biological_process	response to lipopolysaccharide
J	0034976	biological_process	response to endoplasmic reticulum stress
J	0036017	biological_process	response to erythropoietin
J	0036018	biological_process	cellular response to erythropoietin
J	0036466	biological_process	synaptic vesicle recycling via endosome
J	0042542	biological_process	response to hydrogen peroxide
J	0042981	biological_process	regulation of apoptotic process
J	0043027	molecular_function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
J	0043065	biological_process	positive regulation of apoptotic process
J	0043066	biological_process	negative regulation of apoptotic process
J	0043434	biological_process	response to peptide hormone
J	0044877	molecular_function	protein-containing complex binding
J	0051020	molecular_function	GTPase binding
J	0051400	molecular_function	BH domain binding
J	0051602	biological_process	response to electrical stimulus
J	0051707	biological_process	response to other organism
J	0055085	biological_process	transmembrane transport
J	0071320	biological_process	cellular response to cAMP
J	0071347	biological_process	cellular response to interleukin-1
J	0071356	biological_process	cellular response to tumor necrosis factor
J	0071456	biological_process	cellular response to hypoxia
J	0071466	biological_process	cellular response to xenobiotic stimulus
J	0071549	biological_process	cellular response to dexamethasone stimulus
J	0071732	biological_process	cellular response to nitric oxide
J	0072347	biological_process	response to anesthetic
J	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
J	0097371	molecular_function	MDM2/MDM4 family protein binding
J	0098793	cellular_component	presynapse
J	1900118	biological_process	negative regulation of execution phase of apoptosis
J	1900242	biological_process	regulation of synaptic vesicle endocytosis
J	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
J	1900452	biological_process	regulation of long-term synaptic depression
J	1901654	biological_process	response to ketone
J	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
J	1905218	biological_process	cellular response to astaxanthin
J	1990646	biological_process	cellular response to prolactin
J	2000809	biological_process	positive regulation of synaptic vesicle clustering
K	0001541	biological_process	ovarian follicle development
K	0001666	biological_process	response to hypoxia
K	0001836	biological_process	release of cytochrome c from mitochondria
K	0002931	biological_process	response to ischemia
K	0005515	molecular_function	protein binding
K	0005739	cellular_component	mitochondrion
K	0005741	cellular_component	mitochondrial outer membrane
K	0005743	cellular_component	mitochondrial inner membrane
K	0005759	cellular_component	mitochondrial matrix
K	0005813	cellular_component	centrosome
K	0005829	cellular_component	cytosol
K	0005905	cellular_component	clathrin-coated pit
K	0006950	biological_process	response to stress
K	0006979	biological_process	response to oxidative stress
K	0008021	cellular_component	synaptic vesicle
K	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
K	0009410	biological_process	response to xenobiotic stimulus
K	0010288	biological_process	response to lead ion
K	0015267	molecular_function	channel activity
K	0016020	cellular_component	membrane
K	0021987	biological_process	cerebral cortex development
K	0030276	molecular_function	clathrin binding
K	0030672	cellular_component	synaptic vesicle membrane
K	0031965	cellular_component	nuclear membrane
K	0031966	cellular_component	mitochondrial membrane
K	0032465	biological_process	regulation of cytokinesis
K	0032496	biological_process	response to lipopolysaccharide
K	0034976	biological_process	response to endoplasmic reticulum stress
K	0036017	biological_process	response to erythropoietin
K	0036018	biological_process	cellular response to erythropoietin
K	0036466	biological_process	synaptic vesicle recycling via endosome
K	0042542	biological_process	response to hydrogen peroxide
K	0042981	biological_process	regulation of apoptotic process
K	0043027	molecular_function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
K	0043065	biological_process	positive regulation of apoptotic process
K	0043066	biological_process	negative regulation of apoptotic process
K	0043434	biological_process	response to peptide hormone
K	0044877	molecular_function	protein-containing complex binding
K	0051020	molecular_function	GTPase binding
K	0051400	molecular_function	BH domain binding
K	0051602	biological_process	response to electrical stimulus
K	0051707	biological_process	response to other organism
K	0055085	biological_process	transmembrane transport
K	0071320	biological_process	cellular response to cAMP
K	0071347	biological_process	cellular response to interleukin-1
K	0071356	biological_process	cellular response to tumor necrosis factor
K	0071456	biological_process	cellular response to hypoxia
K	0071466	biological_process	cellular response to xenobiotic stimulus
K	0071549	biological_process	cellular response to dexamethasone stimulus
K	0071732	biological_process	cellular response to nitric oxide
K	0072347	biological_process	response to anesthetic
K	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
K	0097371	molecular_function	MDM2/MDM4 family protein binding
K	0098793	cellular_component	presynapse
K	1900118	biological_process	negative regulation of execution phase of apoptosis
K	1900242	biological_process	regulation of synaptic vesicle endocytosis
K	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
K	1900452	biological_process	regulation of long-term synaptic depression
K	1901654	biological_process	response to ketone
K	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
K	1905218	biological_process	cellular response to astaxanthin
K	1990646	biological_process	cellular response to prolactin
K	2000809	biological_process	positive regulation of synaptic vesicle clustering
L	0001541	biological_process	ovarian follicle development
L	0001666	biological_process	response to hypoxia
L	0001836	biological_process	release of cytochrome c from mitochondria
L	0002931	biological_process	response to ischemia
L	0005515	molecular_function	protein binding
L	0005739	cellular_component	mitochondrion
L	0005741	cellular_component	mitochondrial outer membrane
L	0005743	cellular_component	mitochondrial inner membrane
L	0005759	cellular_component	mitochondrial matrix
L	0005813	cellular_component	centrosome
L	0005829	cellular_component	cytosol
L	0005905	cellular_component	clathrin-coated pit
L	0006950	biological_process	response to stress
L	0006979	biological_process	response to oxidative stress
L	0008021	cellular_component	synaptic vesicle
L	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
L	0009410	biological_process	response to xenobiotic stimulus
L	0010288	biological_process	response to lead ion
L	0015267	molecular_function	channel activity
L	0016020	cellular_component	membrane
L	0021987	biological_process	cerebral cortex development
L	0030276	molecular_function	clathrin binding
L	0030672	cellular_component	synaptic vesicle membrane
L	0031965	cellular_component	nuclear membrane
L	0031966	cellular_component	mitochondrial membrane
L	0032465	biological_process	regulation of cytokinesis
L	0032496	biological_process	response to lipopolysaccharide
L	0034976	biological_process	response to endoplasmic reticulum stress
L	0036017	biological_process	response to erythropoietin
L	0036018	biological_process	cellular response to erythropoietin
L	0036466	biological_process	synaptic vesicle recycling via endosome
L	0042542	biological_process	response to hydrogen peroxide
L	0042981	biological_process	regulation of apoptotic process
L	0043027	molecular_function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
L	0043065	biological_process	positive regulation of apoptotic process
L	0043066	biological_process	negative regulation of apoptotic process
L	0043434	biological_process	response to peptide hormone
L	0044877	molecular_function	protein-containing complex binding
L	0051020	molecular_function	GTPase binding
L	0051400	molecular_function	BH domain binding
L	0051602	biological_process	response to electrical stimulus
L	0051707	biological_process	response to other organism
L	0055085	biological_process	transmembrane transport
L	0071320	biological_process	cellular response to cAMP
L	0071347	biological_process	cellular response to interleukin-1
L	0071356	biological_process	cellular response to tumor necrosis factor
L	0071456	biological_process	cellular response to hypoxia
L	0071466	biological_process	cellular response to xenobiotic stimulus
L	0071549	biological_process	cellular response to dexamethasone stimulus
L	0071732	biological_process	cellular response to nitric oxide
L	0072347	biological_process	response to anesthetic
L	0097192	biological_process	extrinsic apoptotic signaling pathway in absence of ligand
L	0097371	molecular_function	MDM2/MDM4 family protein binding
L	0098793	cellular_component	presynapse
L	1900118	biological_process	negative regulation of execution phase of apoptosis
L	1900242	biological_process	regulation of synaptic vesicle endocytosis
L	1900244	biological_process	positive regulation of synaptic vesicle endocytosis
L	1900452	biological_process	regulation of long-term synaptic depression
L	1901654	biological_process	response to ketone
L	1902236	biological_process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
L	1905218	biological_process	cellular response to astaxanthin
L	1990646	biological_process	cellular response to prolactin
L	2000809	biological_process	positive regulation of synaptic vesicle clustering

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 1XJ A 301

Chain	Residue
A	GLU96
A	TYR195
A	HOH404
A	HOH405
B	GLU158
H	TYR120
H	ARG165
H	TRP169
H	HOH406
H	HOH407
A	TYR101
A	PHE105
A	ASN136
A	TRP137
A	GLY138
A	VAL141
A	ALA142
A	PHE191

---

site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 1XJ B 301

Chain	Residue
B	GLU96
B	PHE97
B	ARG100
B	TYR101
B	PHE105
B	GLU129
B	TRP137
B	GLY138
B	VAL141
B	ALA142
B	PHE146
B	PHE191
B	LEU194
B	TYR195
E	MET1
I	TYR120
I	ARG165
I	TRP169
I	THR172

---

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 1XJ C 301

Chain	Residue
C	GLU96
C	PHE97
C	ARG100
C	TYR101
C	PHE105
C	GLU129
C	ASN136
C	TRP137
C	GLY138
C	VAL141
C	ALA142
C	PHE191
C	LEU194
C	TYR195
C	HOH409
G	TYR120
G	ARG165
G	TRP169

---

site_id	AC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 1XJ D 301

Chain	Residue
D	GLU96
D	PHE97
D	ARG100
D	TYR101
D	PHE105
D	LEU108
D	TRP137
D	GLY138
D	VAL141
D	ALA142
D	PHE191
D	TYR195
F	SER2
J	TYR120
J	ARG165
J	TRP169
J	THR172
J	ASP176

---

site_id	AC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 1XJ E 301

Chain	Residue
C	TYR120
C	ARG165
C	TRP169
E	GLU96
E	PHE97
E	TYR101
E	PHE105
E	GLU129
E	ASN136
E	TRP137
E	GLY138
E	VAL141
E	ALA142
E	SER145
E	PHE146
E	PHE191
E	LEU194
E	TYR195

---

site_id	AC6
Number of Residues	21
Details	BINDING SITE FOR RESIDUE 1XJ F 301

Chain	Residue
F	TYR101
F	PHE105
F	GLU129
F	ASN136
F	TRP137
F	GLY138
F	VAL141
F	ALA142
F	SER145
F	PHE146
F	PHE191
F	TYR195
F	HOH410
A	TYR120
A	ARG165
A	TRP169
A	THR172
A	HOH412
F	GLU96
F	PHE97
F	ARG100

---

site_id	AC7
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 1XJ G 301

Chain	Residue
E	TYR120
E	ARG165
E	TRP169
E	THR172
G	GLU96
G	ARG100
G	TYR101
G	PHE105
G	GLU129
G	TRP137
G	GLY138
G	VAL141
G	ALA142
G	PHE191
G	LEU194
G	TYR195
G	HOH404
I	MET1

---

site_id	AC8
Number of Residues	21
Details	BINDING SITE FOR RESIDUE 1XJ H 301

Chain	Residue
F	TYR120
F	ARG165
F	TRP169
F	THR172
F	HOH404
F	HOH409
H	GLU96
H	TYR101
H	PHE105
H	GLU129
H	LEU130
H	TRP137
H	GLY138
H	VAL141
H	ALA142
H	PHE146
H	PHE191
H	TYR195
H	HOH409
J	MET1
J	SER2

---

site_id	AC9
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 1XJ I 301

Chain	Residue
I	GLU96
I	PHE97
I	ARG100
I	TYR101
I	PHE105
I	GLU129
I	LEU130
I	ASN136
I	TRP137
I	GLY138
I	ALA142
I	PHE191
I	TYR195
I	HOH405
I	HOH408
L	TYR120
L	ARG165

---

site_id	BC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE 1XJ J 301

Chain	Residue
J	GLU96
J	PHE97
J	ARG100
J	TYR101
J	PHE105
J	LEU108
J	GLU129
J	LEU130
J	ASN136
J	TRP137
J	GLY138
J	VAL141
J	ALA142
J	PHE191
J	TYR195
J	HOH405
K	TYR120
K	ARG165
K	TRP169
K	ASP176
K	HOH408

---

site_id	BC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 1XJ K 301

Chain	Residue
D	TYR120
D	ARG165
G	GLU158
K	GLU96
K	PHE97
K	TYR101
K	PHE105
K	LEU108
K	LEU130
K	ASN136
K	TRP137
K	GLY138
K	VAL141
K	ALA142
K	PHE191
K	LEU194
K	TYR195
K	HOH403
K	HOH406

---

site_id	BC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE 1XJ L 301

Chain	Residue
B	TYR120
B	ARG165
B	HOH403
H	GLU158
L	GLU96
L	PHE97
L	TYR101
L	PHE105
L	LEU108
L	LEU130
L	TRP137
L	GLY138
L	VAL141
L	ALA142
L	PHE146
L	PHE191
L	LEU194
L	TYR195
L	HOH403
L	HOH406

---

Functional Information from PROSITE/UniProt

site_id	PS01080
Number of Residues	19
Details	BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFsFGG

Chain	Residue	Details
A	LEU130-GLY148

---

site_id	PS01258
Number of Residues	12
Details	BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqenGGWDtFV

Chain	Residue	Details
A	TRP181-VAL192

---

site_id	PS01259
Number of Residues	15
Details	BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VkqaLReAGDEFELR

Chain	Residue	Details
A	VAL86-ARG100

---

site_id	PS01260
Number of Residues	21
Details	BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. SNRELVvDFLSYKLSQKGYsW

Chain	Residue	Details
A	SER4-TRP24

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	240
Details	Motif: {"description":"BH4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	168
Details	Motif: {"description":"BH3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	228
Details	Motif: {"description":"BH1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	180
Details	Motif: {"description":"BH2"}

Chain

Residue

Details

---