4QNQ
Crystal Structure Analysis of full-length Bcl-XL in complex with the inhibitor ABT-263
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Bcl-2-like protein 1 | polymer | 240 | 26854.7 | 12 | UniProt (P53563) Pfam (PF02180) Pfam (PF00452) | Rattus norvegicus (rat) | Bcl2-L-1, Apoptosis regulator Bcl-X |
| 2 | M, N, O, P, Q... (A, B, C, D, E...) | 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]benzamide | non-polymer | 974.6 | 12 | Chemie (1XJ) PubChem (24978538) PubChem (25059310) PubChem (88592356) | |||
| 3 | AA, BA, CA, DA, EA... (C, D, E, F, G...) | water | water | 18.0 | 106 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 1 - 233 (UniProt: P53563)
| PDB | External Database | Details |
|---|---|---|
| Gly -6 | - | expression tag |
| Ser -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Glu -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 322256.0 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 11695.4 | |
| All* | Total formula weight | 333951.3 |
