4QHV

Crystal structure of human dihydrofolate reductase as complex with pyridopyrimidine 22 (N~6~-METHYL-N~6~-[4-(PROPAN-2-YL)PHENYL]PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE)

Summary for 4QHV

Entry DOI	10.2210/pdb4qhv/pdb
Related	4QJC 4QJZ 4ixf
Descriptor	Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N~6~-methyl-N~6~-[4-(propan-2-yl)phenyl]pyrido[2,3-d]pyrimidine-2,4,6-triamine, ... (5 entities in total)
Functional Keywords	inhibitor binding, rossman fold, hydrolase, inhibitor, cofactor nadph, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion : P00374
Total number of polymer chains	1
Total formula weight	22979.71
Authors	Cody, V. (deposition date: 2014-05-29, release date: 2015-06-10, Last modification date: 2023-09-20)
Primary citation	Cody, V.,Pace, J.,Namjoshi, O.A.,Gangjee, A. Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase. Acta Crystallogr F Struct Biol Commun, 71:799-803, 2015 Cited by PubMed: 26057816 DOI: 10.1107/S2053230X15008468 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.61 Å)

Structure validation