4QH3

X-ray structure of the adduct formed between bovine pancreatic ribonuclease and trans-dimethylamine methylamine dichlorido platinum(II)

Summary for 4QH3

• Entry DOI: 10.2210/pdb4qh3/pdb
• Related: 4QGZ
• Descriptor: Ribonuclease pancreatic, bis(chloranyl)-(dimethylamino)-(methylamino)platinum (3 entities in total)
• Functional Keywords: hydrolase, rna binding
• Biological source: Bos taurus (bovine,cow,domestic cattle,domestic cow)
• Cellular location: Secreted: P61823
• Total number of polymer chains: 2
• Total formula weight: 30137.52

Authors

Russo Krauss, I.,Merlino, A. (deposition date: 2014-05-26, release date: 2014-07-30, Last modification date: 2014-08-20)

• Primary citation: Messori, L.,Marzo, T.,Michelucci, E.,Russo Krauss, I.,Navarro-Ranninger, C.,Quiroga, A.G.,Merlino, A.; Interactions between Anticancer trans-Platinum Compounds and Proteins: Crystal Structures and ESI-MS Spectra of Two Protein Adducts of trans-(Dimethylamino)(methylamino)dichloridoplatinum(II).; Inorg.Chem., 53:7806-7808, 2014; PubMed: 25025479; DOI: 10.1021/ic5012583

Experimental method

X-RAY DIFFRACTION (2 Å)