4PXZ

Crystal structure of P2Y12 receptor in complex with 2MeSADP

Summary for 4PXZ

• Entry DOI: 10.2210/pdb4pxz/pdb
• Related: 4NTJ 4PY0
• Descriptor: P2Y purinoceptor 12, Soluble cytochrome b562, 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate), CHOLESTEROL, ... (6 entities in total)
• Functional Keywords: purinergic receptor p2y12, agonist-bound, g-protein coupled receptor (gpcr), membrane protein, signaling protein-agonist complex, psi-biology, gpcr network, structural genomics, signaling membrane protein, gpcr, platelet activation, membrane
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane ; Multi-pass membrane protein : Q9H244
• Total number of polymer chains: 1
• Total formula weight: 55284.57

Authors

Zhang, J.,Zhang, K.,Gao, Z.G.,Paoletta, S.,Zhang, D.,Han, G.W.,Li, T.,Ma, L.,Zhang, W.,Muller, C.E.,Yang, H.,Jiang, H.,Cherezov, V.,Katritch, V.,Jacobson, K.A.,Stevens, R.C.,Wu, B.,Zhao, Q.,GPCR Network (GPCR) (deposition date: 2014-03-25, release date: 2014-04-30, Last modification date: 2023-11-08)

• Primary citation: Zhang, J.,Zhang, K.,Gao, Z.G.,Paoletta, S.,Zhang, D.,Han, G.W.,Li, T.,Ma, L.,Zhang, W.,Muller, C.E.,Yang, H.,Jiang, H.,Cherezov, V.,Katritch, V.,Jacobson, K.A.,Stevens, R.C.,Wu, B.,Zhao, Q.; Agonist-bound structure of the human P2Y12 receptor; Nature, 509:119-122, 2014; PubMed: 24784220; DOI: 10.1038/nature13288

Experimental method

X-RAY DIFFRACTION (2.5 Å)