4PXZ

Crystal structure of P2Y12 receptor in complex with 2MeSADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0005506	molecular_function	iron ion binding
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007194	biological_process	negative regulation of adenylate cyclase activity
A	0007596	biological_process	blood coagulation
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0045028	molecular_function	G protein-coupled purinergic nucleotide receptor activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE 6AD A 1201

Chain	Residue
A	ARG93
A	LYS179
A	HIS187
A	VAL190
A	ASN191
A	CYS194
A	ARG256
A	TYR259
A	GLN263
A	LYS280
A	HOH1319
A	CYS97
A	HOH1322
A	HOH1331
A	HOH1336
A	HOH1348
A	SER101
A	VAL102
A	TYR105
A	SER156
A	ASN159
A	LYS174
A	CYS175

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CLR A 1202

Chain	Residue
A	SER55
A	ILE61
A	LYS64
A	ASN65
A	ILE68
A	TRP149
A	PHE153
A	PHE153

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE OLC A 1203

Chain	Residue
A	GLN98
A	ILE161
A	ASN164

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE OLC A 1204

Chain	Residue
A	ARG231
A	VAL236
A	THR275
A	TYR278
A	SER282
A	OLC1205

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE OLC A 1205

Chain	Residue
A	ASP20
A	ILE23
A	LEU27
A	SER282
A	OLC1204

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG A 1206

Chain	Residue
A	ASN1022
A	GLN1025
A	GLN1041
A	ARG1062
A	HOH1315

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	13
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"description":"axial binding residue"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	Topological domain: {"description":"Cytoplasmic"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	54
Details	Topological domain: {"description":"Extracellular"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	17
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9EPX4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---