4NTJ
Structure of the human P2Y12 receptor in complex with an antithrombotic drug
Summary for 4NTJ
Entry DOI | 10.2210/pdb4ntj/pdb |
Descriptor | P2Y purinoceptor 12,Soluble cytochrome b562,P2Y purinoceptor 12, ethyl 6-{4-[(benzylsulfonyl)carbamoyl]piperidin-1-yl}-5-cyano-2-methylpyridine-3-carboxylate, CHOLESTEROL, ... (5 entities in total) |
Functional Keywords | human p2y12 receptor, gpcr network, membrane protein, lipidic cubic phase, antithrombotic drug, gpcr, psi-biology, structural genomics, signaling protein, membrane |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Multi-pass membrane protein : Q9H244 |
Total number of polymer chains | 1 |
Total formula weight | 55205.81 |
Authors | Zhang, K.,Zhang, J.,Gao, Z.-G.,Zhang, D.,Zhu, L.,Han, G.W.,Moss, S.M.,Paoletta, S.,Kiselev, E.,Lu, W.,Fenalti, G.,Zhang, W.,Muller, C.E.,Yang, H.,Jiang, H.,Cherezov, V.,Katritch, V.,Jacobson, K.A.,Stevens, R.C.,Wu, B.,Zhao, Q.,GPCR Network (GPCR) (deposition date: 2013-12-02, release date: 2014-03-26, Last modification date: 2023-11-08) |
Primary citation | Zhang, K.,Zhang, J.,Gao, Z.-G.,Zhang, D.,Zhu, L.,Han, G.W.,Moss, S.M.,Paoletta, S.,Kiselev, E.,Lu, W.,Fenalti, G.,Zhang, W.,Muller, C.E.,Yang, H.,Jiang, H.,Cherezov, V.,Katritch, V.,Jacobson, K.A.,Stevens, R.C.,Wu, B.,Zhao, Q. Structure of the human P2Y12 receptor in complex with an antithrombotic drug Nature, 509:115-118, 2014 Cited by PubMed: 24670650DOI: 10.1038/nature13083 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.62 Å) |
Structure validation
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