4PS1

Caspase-8 specific unnatural amino acid peptides

Summary for 4PS1

• Entry DOI: 10.2210/pdb4ps1/pdb
• Related: 4JJ7 4JJ8 4JJE 4PRY 4PRZ 4PS0
• Descriptor: Caspase-8, (BAL)LQ(HYP)(1U8) PEPTIDE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... (4 entities in total)
• Functional Keywords: protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q14790
• Total number of polymer chains: 8
• Total formula weight: 129226.54

Authors

Wolan, D.W.,Vickers, C.J.,Gonzalez-Paez, G.E. (deposition date: 2014-03-06, release date: 2015-01-21, Last modification date: 2023-12-06)

• Primary citation: Vickers, C.J.,Gonzalez-Paez, G.E.,Litwin, K.M.,Umotoy, J.C.,Coutsias, E.A.,Wolan, D.W.; Selective inhibition of initiator versus executioner caspases using small peptides containing unnatural amino acids.; Acs Chem.Biol., 9:2194-2198, 2014; PubMed: 25079698; DOI: 10.1021/cb5004256

Experimental method

X-RAY DIFFRACTION (1.731 Å)