Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
| C | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008234 | molecular_function | cysteine-type peptidase activity |
| D | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0008234 | molecular_function | cysteine-type peptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DTT A 501 |
| Chain | Residue |
| A | THR337 |
| A | GLU396 |
| A | THR469 |
| A | HOH669 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DTT B 501 |
| Chain | Residue |
| B | THR337 |
| B | GLU396 |
| B | THR469 |
| B | HOH632 |
| B | HOH643 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DTT C 501 |
| Chain | Residue |
| C | THR337 |
| C | GLU396 |
| C | THR469 |
| C | HOH626 |
| D | HOH743 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DTT D 501 |
| Chain | Residue |
| C | HOH680 |
| D | THR337 |
| D | GLU396 |
| D | THR469 |
| D | HOH647 |
Functional Information from PROSITE/UniProt
| site_id | PS01121 |
| Number of Residues | 15 |
| Details | CASPASE_HIS Caspase family histidine active site. HsnmdCfiCcILSHG |
| Chain | Residue | Details |
| A | HIS304-GLY318 | |
| site_id | PS01122 |
| Number of Residues | 12 |
| Details | CASPASE_CYS Caspase family cysteine active site. KPKVFFIQACQG |
| Chain | Residue | Details |
| A | LYS351-GLY362 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"10508785","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O89110","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"(Microbial infection) ADP-riboxanated arginine","evidences":[{"source":"PubMed","id":"35338844","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35446120","evidenceCode":"ECO:0000269"}]} |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 818 |
| Chain | Residue | Details |
| A | ARG258 | electrostatic stabiliser |
| A | HIS317 | proton acceptor, proton donor |
| A | GLY318 | electrostatic stabiliser |
| A | CYS360 | nucleofuge, nucleophile, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 818 |
| Chain | Residue | Details |
| B | ARG258 | electrostatic stabiliser |
| B | HIS317 | proton acceptor, proton donor |
| B | GLY318 | electrostatic stabiliser |
| B | CYS360 | nucleofuge, nucleophile, proton acceptor, proton donor |
| site_id | MCSA3 |
| Number of Residues | 4 |
| Details | M-CSA 818 |
| Chain | Residue | Details |
| C | ARG258 | electrostatic stabiliser |
| C | HIS317 | proton acceptor, proton donor |
| C | GLY318 | electrostatic stabiliser |
| C | CYS360 | nucleofuge, nucleophile, proton acceptor, proton donor |
| site_id | MCSA4 |
| Number of Residues | 4 |
| Details | M-CSA 818 |
| Chain | Residue | Details |
| D | ARG258 | electrostatic stabiliser |
| D | HIS317 | proton acceptor, proton donor |
| D | GLY318 | electrostatic stabiliser |
| D | CYS360 | nucleofuge, nucleophile, proton acceptor, proton donor |
