4PNZ
Human dipeptidyl peptidase IV/CD26 in complex with the long-acting inhibitor Omarigliptin (MK-3102)
Summary for 4PNZ
Entry DOI | 10.2210/pdb4pnz/pdb |
Descriptor | Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ... (6 entities in total) |
Functional Keywords | alpha/beta, beta-propeller, dimer, diabetes, aminopeptidase, cell membrane, disulfide bond, glycoprotein, secreted, serine protease, signal-anchor, transmembrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 173700.79 |
Authors | Scapin, G.,Yan, Y. (deposition date: 2014-02-22, release date: 2014-04-09, Last modification date: 2023-09-20) |
Primary citation | Biftu, T.,Sinha-Roy, R.,Chen, P.,Qian, X.,Feng, D.,Kuethe, J.T.,Scapin, G.,Gao, Y.D.,Yan, Y.,Krueger, D.,Bak, A.,Eiermann, G.,He, J.,Cox, J.,Hicks, J.,Lyons, K.,He, H.,Salituro, G.,Tong, S.,Patel, S.,Doss, G.,Petrov, A.,Wu, J.,Xu, S.S.,Sewall, C.,Zhang, X.,Zhang, B.,Thornberry, N.A.,Weber, A.E. Omarigliptin (MK-3102): A Novel Long-Acting DPP-4 Inhibitor for Once-Weekly Treatment of Type 2 Diabetes. J.Med.Chem., 57:3205-3212, 2014 Cited by PubMed: 24660890DOI: 10.1021/jm401992e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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