4PNZ
Human dipeptidyl peptidase IV/CD26 in complex with the long-acting inhibitor Omarigliptin (MK-3102)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dipeptidyl peptidase 4 | polymer | 728 | 84476.6 | 2 | UniProt (P27487) Pfam (PF00930) Pfam (PF00326) | Homo sapiens (human) | ADABP, Adenosine deaminase complexing protein 2, ADCP-2, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, TP103, Dipeptidyl peptidase 4 soluble form, Dipeptidyl peptidase IV soluble form |
| 2 | C, D, E, F, G (C, D, E, F, G) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 3 | H (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | I, M (A, B) | (2R,3S,5R)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-amine | non-polymer | 416.4 | 2 | Chemie (2VH) | |||
| 5 | J, K, L, N, O... (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
| 6 | S, T (A, B) | water | water | 18.0 | 1624 | Chemie (HOH) |
Sequence modifications
A, B: 39 - 766 (UniProt: P27487)
| PDB | External Database | Details |
|---|---|---|
| Thr 39 | Ser 39 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 168953.3 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2122.0 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2625.5 | |
| All* | Total formula weight | 173700.8 |
