4PDQ
Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neomycin analog
Summary for 4PDQ
Entry DOI | 10.2210/pdb4pdq/pdb |
Descriptor | RNA (5'-*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C-3'), MAGNESIUM ION, (2S)-4-amino-N-{(1R,2S,3R,4R,5S)-5-amino-3-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy }-4-[(2,6-diamino-2,4,6-trideoxy-4-fluoro-alpha-D-galactopyranosyl)oxy]-2-hydroxycyclohexyl}-2-hydroxybutanamide, ... (4 entities in total) |
Functional Keywords | ribosome, aminoglycoside, rna-antibiotic complex, rna/antibiotic |
Biological source | synthetic |
Total number of polymer chains | 2 |
Total formula weight | 15507.20 |
Authors | Hanessian, S.,Saavedra, O.M.,Vilchis-Reyes, M.A.,Maianti, J.P.,Kanazawa, H.,Dozzo, P.,Feeney, L.A.,Armstrong, E.S.,Kondo, J. (deposition date: 2014-04-21, release date: 2015-01-07, Last modification date: 2024-03-20) |
Primary citation | Hanessian, S.,Saavedra, O.M.,Vilchis-Reyes, M.A.,Maianti, J.P.,Kanazawa, H.,Dozzo, P.,Matias, R.D.,Serio, A.,Kondo, J. Synthesis, broad spectrum antibacterial activity, and X-ray co-crystal structure of the decoding bacterial ribosomal A-site with 4'-deoxy-4'-fluoro neomycin analogs Chem Sci, 5:4621-4632, 2014 Cited by DOI: 10.1039/C4SC01626BPDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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