4PA0
Omecamtiv Mercarbil binding site on the Human Beta-Cardiac Myosin Motor Domain
Summary for 4PA0
Entry DOI | 10.2210/pdb4pa0/pdb |
Related | 4P7H |
Descriptor | Myosin-7,Green fluorescent protein, methyl 4-(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}benzyl)piperazine-1-carboxylate, GLYCEROL, ... (4 entities in total) |
Functional Keywords | cardiac, myosin, motor, omecamtiv mercarbil, motor-fluorescent protein complex, motor/fluorescent protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 234298.78 |
Authors | Winkelmann, D.A.,Miller, M.T.,Stock, A.M. (deposition date: 2014-04-06, release date: 2015-07-08, Last modification date: 2023-11-15) |
Primary citation | Winkelmann, D.A.,Forgacs, E.,Miller, M.T.,Stock, A.M. Structural basis for drug-induced allosteric changes to human beta-cardiac myosin motor activity. Nat Commun, 6:7974-7974, 2015 Cited by PubMed: 26246073DOI: 10.1038/ncomms8974 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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