4P2T
Crystal structure of Kaposi's sarcoma-associated herpesvirus (KSHV) protease in complex with a dimer disruptor
Summary for 4P2T
Entry DOI | 10.2210/pdb4p2t/pdb |
Descriptor | KSHV Protease, 6-(cyclohexylmethyl)-N-[4-(methylsulfonylcarbamoyl)-2-(phenylmethyl)phenyl]pyridine-2-carboxamide, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | protein-protein interaction inhibition, serine protease, inhibitor complex, beta barrel and alpha helices, hydrolase |
Biological source | Human herpesvirus 8 (HHV-8) |
Total number of polymer chains | 2 |
Total formula weight | 44237.50 |
Authors | Gable, J.E. (deposition date: 2014-03-04, release date: 2014-07-16, Last modification date: 2023-09-27) |
Primary citation | Gable, J.E.,Lee, G.M.,Jaishankar, P.,Hearn, B.R.,Waddling, C.A.,Renslo, A.R.,Craik, C.S. Broad-spectrum allosteric inhibition of herpesvirus proteases. Biochemistry, 53:4648-4660, 2014 Cited by PubMed: 24977643DOI: 10.1021/bi5003234 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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