4OIV
Structural basis for small molecule NDB as a selective antagonist of FXR
Summary for 4OIV
Entry DOI | 10.2210/pdb4oiv/pdb |
Descriptor | Bile acid receptor, N-benzyl-N-(3-tert-butyl-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino)benzamide (3 entities in total) |
Functional Keywords | bile acid sensor, nuclear, nuclear protein receptor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : Q96RI1 |
Total number of polymer chains | 2 |
Total formula weight | 53967.60 |
Authors | |
Primary citation | Xu, X.,Xu, X.,Liu, P.,Zhu, Z.Y.,Chen, J.,Fu, H.A.,Chen, L.L.,Hu, L.H.,Shen, X. Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor alpha (FXR alpha ) in Stabilizing the Homodimerization of the Receptor. J.Biol.Chem., 290:19888-19899, 2015 Cited by PubMed: 26100621DOI: 10.1074/jbc.M114.630475 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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