4OAV
Complete human RNase L in complex with 2-5A (5'-ppp heptamer), AMPPCP and RNA substrate.
Summary for 4OAV
Entry DOI | 10.2210/pdb4oav/pdb |
Related | 4OAU |
Descriptor | PROTEIN (RNase L), RNA (5'-R(P*(PO4)P*(PO4)P*AP*AP*AP*AP*(PO4))-2'), PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (6 entities in total) |
Functional Keywords | hpc1, 2-5a, 2', 5'-oligoadenylate, interferon, dsrna, kinase, rnase, ridd, ire1, rna decay, rnase l protein kinase, pseudokinase, ken-domain containing, regulated rna decay, innate immune response, antiviral response, dsrna response, 5'-linked oligoadenylates; rna, hydrolase-rna complex, hydrolase/rna |
Biological source | Homo sapiens More |
Cellular location | Cytoplasm: Q05823 |
Total number of polymer chains | 4 |
Total formula weight | 163466.07 |
Authors | Han, Y.,Donovan, J.,Rath, S.,Whitney, G.,Chitrakar, A.,Korennykh, A. (deposition date: 2014-01-06, release date: 2014-03-12, Last modification date: 2023-09-20) |
Primary citation | Han, Y.,Donovan, J.,Rath, S.,Whitney, G.,Chitrakar, A.,Korennykh, A. Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response. Science, 343:1244-1248, 2014 Cited by PubMed: 24578532DOI: 10.1126/science.1249845 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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