4O75
Crystal structure of the first bromodomain of human BRD4 in complex with FOSTAMATINIB
Summary for 4O75
Entry DOI | 10.2210/pdb4o75/pdb |
Related | 4O70 4O71 4O72 4O73 4O74 4O76 4O77 4O78 4O7A 4O7B 4O7C 4O7E 4O7F |
Descriptor | Bromodomain-containing protein 4, [6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | bromodomain, cap, hunk1, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, cell cycle, inhibitor, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15803.98 |
Authors | Zhu, J.-Y.,Ember, S.W.,Watts, C.,Schonbrunn, E. (deposition date: 2013-12-24, release date: 2014-03-05, Last modification date: 2023-09-20) |
Primary citation | Ember, S.W.,Zhu, J.Y.,Olesen, S.H.,Martin, M.P.,Becker, A.,Berndt, N.,Georg, G.I.,Schonbrunn, E. Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors. Acs Chem.Biol., 9:1160-1171, 2014 Cited by PubMed: 24568369DOI: 10.1021/cb500072z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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