Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4O75

Crystal structure of the first bromodomain of human BRD4 in complex with FOSTAMATINIB

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ABromodomain-containing protein 4polymer12715099.41UniProt (O60885)
Pfam (PF00439)
In PDB
Homo sapiens (human)Protein HUNK1
2A[6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphatenon-polymer580.51Chemie (2RC)
3A1,2-ETHANEDIOLnon-polymer62.12Chemie (EDO)
4waterwater18.0110Chemie (HOH)
Sequence modifications
A: 44 - 168 (UniProt: O60885)
PDBExternal DatabaseDetails
Ser 42-expression tag
Met 43-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight15099.4
Non-Polymers*Number of molecules3
Total formula weight704.6
All*Total formula weight15804.0
*Water molecules are not included.

223790

PDB entries from 2024-08-14

PDB statisticsPDBj update infoContact PDBjnumon