4O75

Crystal structure of the first bromodomain of human BRD4 in complex with FOSTAMATINIB

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 2RC A 201

Chain	Residue
A	LYS57
A	TYR97
A	LYS99
A	LYS102
A	ASN117
A	TYR139
A	ASN140
A	EDO202
A	HOH345
A	HOH401
A	ARG58
A	GLN59
A	TRP81
A	PRO82
A	GLN85
A	VAL87
A	LYS91
A	LEU92

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 202

Chain	Residue
A	2RC201
A	HOH368

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 203

Chain	Residue
A	SER51
A	PRO53
A	TRP81
A	MET149
A	HOH361
A	HOH391

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Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA80-TYR139

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	106
Details	Domain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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