4O75

Crystal structure of the first bromodomain of human BRD4 in complex with FOSTAMATINIB

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 2RC A 201

Chain	Residue
A	LYS57
A	TYR97
A	LYS99
A	LYS102
A	ASN117
A	TYR139
A	ASN140
A	EDO202
A	HOH345
A	HOH401
A	ARG58
A	GLN59
A	TRP81
A	PRO82
A	GLN85
A	VAL87
A	LYS91
A	LEU92

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 202

Chain	Residue
A	2RC201
A	HOH368

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 203

Chain	Residue
A	SER51
A	PRO53
A	TRP81
A	MET149
A	HOH361
A	HOH391

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA80-TYR139

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Acetylated histone binding => ECO:0000269|PubMed:22464331

Chain	Residue	Details
A	ASN140

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS99

---