4O1Z
Crystal Structure of Ovine Cyclooxygenase-1 Complex with Meloxicam
Summary for 4O1Z
Entry DOI | 10.2210/pdb4o1z/pdb |
Related | 1DIY 1Q4G 4M11 |
Descriptor | Prostaglandin G/H synthase 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total) |
Functional Keywords | dioxygenase, peroxidase, nsaids, glycosylation, membrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Ovis aries (domestic sheep,lambs,wild sheep) |
Total number of polymer chains | 2 |
Total formula weight | 135246.22 |
Authors | Xu, S.,Hermanson, D.J.,Banerjee, S.,Ghebreselasie, K.,Clayton, G.M.,Garavito, R.M.,Marnett, L.J. (deposition date: 2013-12-16, release date: 2014-01-22, Last modification date: 2023-09-20) |
Primary citation | Xu, S.,Hermanson, D.J.,Banerjee, S.,Ghebreselasie, K.,Clayton, G.M.,Garavito, R.M.,Marnett, L.J. Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network. J.Biol.Chem., 289:6799-6808, 2014 Cited by PubMed: 24425867DOI: 10.1074/jbc.M113.517987 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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