4NW7
PDE4 catalytic domain
Summary for 4NW7
| Entry DOI | 10.2210/pdb4nw7/pdb |
| Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ... (7 entities in total) |
| Functional Keywords | phosphodiesterase, pde4, catalytic, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 43679.10 |
| Authors | Fox III, D.,Edwards, T.E. (deposition date: 2013-12-05, release date: 2014-10-15, Last modification date: 2024-02-28) |
| Primary citation | Hagen, T.J.,Mo, X.,Burgin, A.B.,Fox, D.,Zhang, Z.,Gurney, M.E. Discovery of triazines as selective PDE4B versus PDE4D inhibitors. Bioorg.Med.Chem.Lett., 24:4031-4034, 2014 Cited by PubMed: 24998378DOI: 10.1016/j.bmcl.2014.06.002 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
Download full validation report
