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4NW7

PDE4 catalytic domain

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE ZN A 701
ChainResidue
AHIS410
AHIS446
AASP447
AASP564
AHOH914
AHOH959

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 702
ChainResidue
AHOH852
AHOH856
AHOH959
AASP447
AHOH824
AHOH826

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NA A 703
ChainResidue
AASP397
ATYR399
AHOH908
AHOH910
AHOH956
AHOH957

site_idAC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 2O5 A 704
ChainResidue
ASER454
AMET519
AASN567
APHE586
AMET603
AGLN615
APHE618
APHE678
AEDO710
AHOH918

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 705
ChainResidue
AASN361
APRO363
ASER408
ALEU409
AHOH820
AHOH913

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 706
ChainResidue
AGLN373
AASP647
AHOH900
AHOH991

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 707
ChainResidue
AHIS491
ACYS492
AASP493
AMET496
ASER654
AHOH843

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE EDO A 708
ChainResidue
AHIS322
ASER326
ASER385
AASP386
AILE389
ASER540

site_idAC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO A 709
ChainResidue
AVAL430
ATHR432
AARG552

site_idBC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 710
ChainResidue
APHE586
APRO602
ACYS604
A2O5704

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF
ChainResidueDetails
AHIS446-PHE457

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton donor => ECO:0000305|PubMed:15003452, ECO:0007744|PDB:1ROR
ChainResidueDetails
AHIS406

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5
ChainResidueDetails
AGLN615
AHIS406

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:15685167, ECO:0000269|PubMed:17727341, ECO:0000269|PubMed:18539455, ECO:0007744|PDB:1RO6, ECO:0007744|PDB:1RO9, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5, ECO:0007744|PDB:1XLX, ECO:0007744|PDB:1XLZ, ECO:0007744|PDB:1XM4, ECO:0007744|PDB:1XM6, ECO:0007744|PDB:1XMU, ECO:0007744|PDB:1XMY, ECO:0007744|PDB:1XN0, ECO:0007744|PDB:1XOS, ECO:0007744|PDB:1XOT, ECO:0007744|PDB:1Y2H, ECO:0007744|PDB:1Y2J, ECO:0007744|PDB:2QYL, ECO:0007744|PDB:3D3P
ChainResidueDetails
AHIS410

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:15685167, ECO:0000269|PubMed:17727341, ECO:0000269|PubMed:18539455, ECO:0007744|PDB:1F0J, ECO:0007744|PDB:1RO6, ECO:0007744|PDB:1RO9, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1XLX, ECO:0007744|PDB:1XLZ, ECO:0007744|PDB:1XM4, ECO:0007744|PDB:1XM6, ECO:0007744|PDB:1XMU, ECO:0007744|PDB:1XMY, ECO:0007744|PDB:1XN0, ECO:0007744|PDB:1XOS, ECO:0007744|PDB:1XOT, ECO:0007744|PDB:1Y2H, ECO:0007744|PDB:1Y2J, ECO:0007744|PDB:2QYL, ECO:0007744|PDB:3D3P
ChainResidueDetails
AHIS446

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:15003452, ECO:0007744|PDB:1ROR
ChainResidueDetails
AASP447

site_idSWS_FT_FI6
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:15685167, ECO:0000269|PubMed:18539455, ECO:0007744|PDB:1F0J, ECO:0007744|PDB:1RO6, ECO:0007744|PDB:1RO9, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5, ECO:0007744|PDB:1XLX, ECO:0007744|PDB:1XLZ, ECO:0007744|PDB:1XM4, ECO:0007744|PDB:1XM6, ECO:0007744|PDB:1XMU, ECO:0007744|PDB:1XMY, ECO:0007744|PDB:1XN0, ECO:0007744|PDB:1XOS, ECO:0007744|PDB:1XOT, ECO:0007744|PDB:1Y2H, ECO:0007744|PDB:1Y2J, ECO:0007744|PDB:3D3P
ChainResidueDetails
AASP564

site_idSWS_FT_FI7
Number of Residues1
DetailsBINDING: BINDING => ECO:0000305|PubMed:15003452, ECO:0000305|PubMed:15260978, ECO:0007744|PDB:1ROR, ECO:0007744|PDB:1TB5
ChainResidueDetails
APHE618

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P14646
ChainResidueDetails
ASER661
ASER659

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PDB entries from 2024-06-12

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