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4N9L

crystal structure of beta-lactamse PenP_E166S in complex with meropenem

Summary for 4N9L
Entry DOI10.2210/pdb4n9l/pdb
Related4N92 4N9K
DescriptorBeta-lactamase, (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid (3 entities in total)
Functional Keywordshydrolase, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological sourceBacillus licheniformis
Cellular locationCell membrane; Lipid-anchor (Probable): P00808
Total number of polymer chains2
Total formula weight60342.49
Authors
Pan, X.,Wong, W.,Zhao, Y. (deposition date: 2013-10-21, release date: 2014-09-10, Last modification date: 2022-02-09)
Primary citationPan, X.,Wong, W.,He, Y.,Jiang, Y.,Zhao, Y.
Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation
Biochemistry, 53:5414-5423, 2014
Cited by
PubMed: 25020031
DOI: 10.1021/bi401609h
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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