Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4N9L

crystal structure of beta-lactamse PenP_E166S in complex with meropenem

Functional Information from GO Data
ChainGOidnamespacecontents
A0005886cellular_componentplasma membrane
A0008800molecular_functionbeta-lactamase activity
A0016787molecular_functionhydrolase activity
A0017001biological_processantibiotic catabolic process
A0030655biological_processbeta-lactam antibiotic catabolic process
A0046677biological_processresponse to antibiotic
B0005886cellular_componentplasma membrane
B0008800molecular_functionbeta-lactamase activity
B0016787molecular_functionhydrolase activity
B0017001biological_processantibiotic catabolic process
B0030655biological_processbeta-lactam antibiotic catabolic process
B0046677biological_processresponse to antibiotic
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE DWZ B 400
ChainResidue
BALA69
BHOH533
BHOH569
BHOH611
BHOH649
BSER70
BSER130
BASN132
BLYS234
BTHR235
BGLY236
BALA237
BTYR274

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE DWZ A 400
ChainResidue
AALA69
ASER70
ASER130
AASN132
ATHR235
AGLY236
AALA237
ATYR274
AHOH536
AHOH615

Functional Information from PROSITE/UniProt
site_idPS00141
Number of Residues12
DetailsASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. FALDTGTNRTVA
ChainResidueDetails
BPHE47-ALA59

site_idPS00146
Number of Residues16
DetailsBETA_LACTAMASE_A Beta-lactamase class-A active site. FaFASTiKaltVGVLL
ChainResidueDetails
BPHE66-LEU81

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Acyl-ester intermediate
ChainResidueDetails
BSER70
ASER70

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
BGLU168
AGLU168

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING:
ChainResidueDetails
BLYS234
ALYS234

227344

PDB entries from 2024-11-13

PDB statisticsPDBj update infoContact PDBjnumon