4MQ9

Crystal structure of Thermus thermophilus RNA polymerase holoenzyme in complex with GE23077

Summary for 4MQ9

• Entry DOI: 10.2210/pdb4mq9/pdb
• Related PRD ID: PRD_001181
• Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... (10 entities in total)
• Functional Keywords: dna-directed rna polymerase, transcription, transferase-antibiotic complex, transferase/antibiotic
• Biological source: Thermus thermophilus; More
• Cellular location: Cytoplasm (By similarity): Q5SKW1
• Total number of polymer chains: 7
• Total formula weight: 429585.67

Authors

Ho, M.X.,Arnold, E.,Ebright, R.H.,Zhang, Y.,Tuske, S. (deposition date: 2013-09-16, release date: 2014-05-07, Last modification date: 2023-09-20)

• Primary citation: Zhang, Y.,Degen, D.,Ho, M.X.,Sineva, E.,Ebright, K.Y.,Ebright, Y.W.,Mekler, V.,Vahedian-Movahed, H.,Feng, Y.,Yin, R.,Tuske, S.,Irschik, H.,Jansen, R.,Maffioli, S.,Donadio, S.,Arnold, E.,Ebright, R.H.; GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.; Elife, 3:e02450-e02450, 2014; PubMed: 24755292

Experimental method

X-RAY DIFFRACTION (3.35 Å)