4M49
Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18
Summary for 4M49
Entry DOI | 10.2210/pdb4m49/pdb |
Related | 4JNK |
Descriptor | L-lactate dehydrogenase A chain, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (7 entities in total) |
Functional Keywords | dehydrogenase/reductase, nicotinamide adenine dinucleotide nadh, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00338 |
Total number of polymer chains | 4 |
Total formula weight | 151275.29 |
Authors | Eigenbrot, C.,Ultsch, M. (deposition date: 2013-08-06, release date: 2013-09-04, Last modification date: 2023-11-15) |
Primary citation | Fauber, B.P.,Dragovich, P.S.,Chen, J.,Corson, L.B.,Ding, C.Z.,Eigenbrot, C.,Giannetti, A.M.,Hunsaker, T.,Labadie, S.,Liu, Y.,Liu, Y.,Malek, S.,Peterson, D.,Pitts, K.,Sideris, S.,Ultsch, M.,Vanderporten, E.,Wang, J.,Wei, B.,Yen, I.,Yue, Q. Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase. Bioorg.Med.Chem.Lett., 23:5533-5539, 2013 Cited by PubMed: 24012183DOI: 10.1016/j.bmcl.2013.08.060 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.052 Å) |
Structure validation
Download full validation report