4M0R
Trianthranilate-like analogue bound to anthranilate phosphoribosyltransferase (AnPRT; TrpD).
Summary for 4M0R
Entry DOI | 10.2210/pdb4m0r/pdb |
Related | 4GIU 4GKM 4IJ1 |
Descriptor | Anthranilate phosphoribosyltransferase, 2,6-bis[(2-carboxyphenyl)amino]benzoic acid, GLYCEROL, ... (6 entities in total) |
Functional Keywords | magnesium binding, phosphoribosylpyrophosphate, prpp, inhibitor complex, tri-anthranilate analogue, tb structural genomics consortium, tbsgc, phosphoribosyltransferase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 78998.19 |
Authors | Evans, G.L.,Baker, E.N.,Lott, J.S.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2013-08-02, release date: 2014-05-21, Last modification date: 2023-09-20) |
Primary citation | Evans, G.L.,Gamage, S.A.,Bulloch, E.M.,Baker, E.N.,Denny, W.A.,Lott, J.S. Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis. Chembiochem, 15:852-864, 2014 Cited by PubMed: 24623674DOI: 10.1002/cbic.201300628 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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